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Prenatal origins of hospitalization for personality disorders: The Helsinki Birth Cohort Study

Prenatal origins of hospitalization for personality disorders: The Helsinki Birth Cohort Study
Prenatal origins of hospitalization for personality disorders: The Helsinki Birth Cohort Study
Although a suboptimal prenatal environment has been linked with schizophrenia and depression, possible associations with personality disorders remain unclear. The aim of this study was to examine the associations of body size at birth and length of gestation with hospitalization for personality disorders in a cohort study of 6506 men and 5857 women born in Helsinki, Finland, between 1934 and 1944. International Classification of Diseases (-8, -9, -10) diagnoses of personality disorders were extracted from the national Finnish Hospital Discharge Register since 1969. 102 men and 80 women had been hospitalized due to any personality disorder. 41 men and 30 women had dramatic personality disorders. Among men, head circumference showed an inverse J-shaped, nonlinear association with hospitalization for personality disorders. Men with a small head circumference were at increased risk. Also in men, a smaller head-to-length ratio linearly predicted personality disorders. Among women, a smaller placental area predicted increased risk of hospitalization for dramatic personality disorders. Vulnerability to personality disorders may be programmed during fetal life
226-230
Lahti, Marius
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Raikkonen, Katri
7f44cbef-84f3-4d77-9ccc-f026ce537dd8
Wahlbeck, Kristian
b88af34b-f33b-4b72-94f9-6fc06d0ed0c1
Heinonen, Kati
46bb57d0-1c33-4cdd-badf-d38a5fc61200
Forsen, Tom
77245dbe-fc1f-4e6f-a2bb-6f1a77918cd2
Kajantie, Eero
d68d55b6-6df1-4195-a914-44c738a6db93
Pesonen, Anu-Katriina
8cc53fef-f713-425e-bd01-8f1c53842351
Osmond, Clive
2677bf85-494f-4a78-adf8-580e1b8acb81
Barker, David J.P.
5c773838-b094-4ac1-999b-b5869717f243
Eriksson, Johan G.
eb96b1c5-af07-4a52-8a73-7541451d32cd
Lahti, Marius
fd381704-d07d-4e9a-b592-adf2313d8bd6
Raikkonen, Katri
7f44cbef-84f3-4d77-9ccc-f026ce537dd8
Wahlbeck, Kristian
b88af34b-f33b-4b72-94f9-6fc06d0ed0c1
Heinonen, Kati
46bb57d0-1c33-4cdd-badf-d38a5fc61200
Forsen, Tom
77245dbe-fc1f-4e6f-a2bb-6f1a77918cd2
Kajantie, Eero
d68d55b6-6df1-4195-a914-44c738a6db93
Pesonen, Anu-Katriina
8cc53fef-f713-425e-bd01-8f1c53842351
Osmond, Clive
2677bf85-494f-4a78-adf8-580e1b8acb81
Barker, David J.P.
5c773838-b094-4ac1-999b-b5869717f243
Eriksson, Johan G.
eb96b1c5-af07-4a52-8a73-7541451d32cd

Lahti, Marius, Raikkonen, Katri, Wahlbeck, Kristian, Heinonen, Kati, Forsen, Tom, Kajantie, Eero, Pesonen, Anu-Katriina, Osmond, Clive, Barker, David J.P. and Eriksson, Johan G. (2010) Prenatal origins of hospitalization for personality disorders: The Helsinki Birth Cohort Study. Psychiatry Research, 179 (2), 226-230. (doi:10.1016/j.psychres.2009.08.024). (PMID:20493545)

Record type: Article

Abstract

Although a suboptimal prenatal environment has been linked with schizophrenia and depression, possible associations with personality disorders remain unclear. The aim of this study was to examine the associations of body size at birth and length of gestation with hospitalization for personality disorders in a cohort study of 6506 men and 5857 women born in Helsinki, Finland, between 1934 and 1944. International Classification of Diseases (-8, -9, -10) diagnoses of personality disorders were extracted from the national Finnish Hospital Discharge Register since 1969. 102 men and 80 women had been hospitalized due to any personality disorder. 41 men and 30 women had dramatic personality disorders. Among men, head circumference showed an inverse J-shaped, nonlinear association with hospitalization for personality disorders. Men with a small head circumference were at increased risk. Also in men, a smaller head-to-length ratio linearly predicted personality disorders. Among women, a smaller placental area predicted increased risk of hospitalization for dramatic personality disorders. Vulnerability to personality disorders may be programmed during fetal life

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Published date: September 2010

Identifiers

Local EPrints ID: 165213
URI: http://eprints.soton.ac.uk/id/eprint/165213
PURE UUID: 7b1c8a6f-bf7f-4349-9878-4ba54ad126fc
ORCID for Clive Osmond: ORCID iD orcid.org/0000-0002-9054-4655

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Date deposited: 08 Oct 2010 14:01
Last modified: 14 Mar 2024 02:38

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Contributors

Author: Marius Lahti
Author: Katri Raikkonen
Author: Kristian Wahlbeck
Author: Kati Heinonen
Author: Tom Forsen
Author: Eero Kajantie
Author: Anu-Katriina Pesonen
Author: Clive Osmond ORCID iD
Author: David J.P. Barker
Author: Johan G. Eriksson

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