Childhood cognitive ability: relationship to gestational diabetes mellitus in India
Veena, S.R., Krishnaveni, G.V., Srinivasan, K., Kurpad, A.V., Muthayya, S, Hill, J.C., Kiran, K.N. and Fall, C.H. (2010) Childhood cognitive ability: relationship to gestational diabetes mellitus in India. Diabetologia, 53, (10), 2134-2138. (doi:10.1007/s00125-010-1847-0 ). (PMID:20614102).
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Description/Abstract
Aims/hypothesis: Our aim was to test the hypothesis that gestational diabetes mellitus (GDM) in mothers is associated with poorer cognitive ability in their offspring in India.
Methods: During 1997 to 1998 maternal GDM status was assessed by OGTT at 30 ± 2 weeks of gestation. Between 2007 and 2008, at a mean age of 9.7 years, 515 children (32 offspring of GDM mothers [ODM]; 483 offspring of non-GDM mothers [controls]) from the Mysore Parthenon birth cohort underwent cognitive function assessment using tests from the Kaufman Assessment Battery for Children—Second Edition and additional tests measuring learning, long-term storage/retrieval, short-term memory, reasoning, attention and concentration, and visuo-spatial and verbal abilities.
Results: Compared with controls, ODM scored higher in tests for learning, long-term retrieval/storage (p = 0.008), reasoning (p = 0.02), verbal ability (p = 0.01), and attention and concentration (p = 0.003). In multiple regression, adjusted for the child’s age, sex, gestation, neonatal weight and head circumference, maternal age, parity and BMI, and the parent’s socioeconomic status, education and rural/urban residence, this difference remained significant only for learning, long-term retrieval/storage (β = 0.4 SD (95% CI 0.01–0.75); p = 0.04) and verbal ability (β = 0.5 SD (95% CI 0.09–0.83); p = 0.02), and not with other test scores.
Conclusions/interpretation: In this population of healthy Indian children, there was no evidence of lower cognitive ability in ODM. In fact some cognitive scores were higher in ODM.
| Item Type: | Article |
|---|---|
| ISSNs: | 0012-186X (print) 1432-0428 (electronic) |
| Keywords: | children, cognitive function, gestational diabetes mellitus, india |
| Subjects: | R Medicine > RB Pathology R Medicine > RG Gynecology and obstetrics R Medicine > RJ Pediatrics > RJ101 Child Health. Child health services |
| Divisions: | University Structure - Pre August 2011 > School of Medicine |
| Item ID: | 165453 |
| Date Deposited: | 12 Oct 2010 15:22 |
| Last Modified: | 01 Jun 2011 03:19 |
| Contributors: | Veena, S.R. (Author) Krishnaveni, G.V. (Author) Srinivasan, K. (Author) Kurpad, A.V. (Author) Muthayya, S (Author) Hill, J.C. (Author) Kiran, K.N. (Author) Fall, C.H. (Author) |
| Date: | October 2010 |
| Status: | Published |
| URI: | http://eprints.soton.ac.uk/id/eprint/165453 |
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