Childhood cognitive ability: relationship to gestational diabetes mellitus in India


Veena, S.R., Krishnaveni, G.V., Srinivasan, K., Kurpad, A.V., Muthayya, S, Hill, J.C., Kiran, K.N. and Fall, C.H. (2010) Childhood cognitive ability: relationship to gestational diabetes mellitus in India. Diabetologia, 53, (10), 2134-2138. (doi:10.1007/s00125-010-1847-0 ). (PMID:20614102).

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Description/Abstract

Aims/hypothesis: Our aim was to test the hypothesis that gestational diabetes mellitus (GDM) in mothers is associated with poorer cognitive ability in their offspring in India.

Methods: During 1997 to 1998 maternal GDM status was assessed by OGTT at 30 ± 2 weeks of gestation. Between 2007 and 2008, at a mean age of 9.7 years, 515 children (32 offspring of GDM mothers [ODM]; 483 offspring of non-GDM mothers [controls]) from the Mysore Parthenon birth cohort underwent cognitive function assessment using tests from the Kaufman Assessment Battery for Children—Second Edition and additional tests measuring learning, long-term storage/retrieval, short-term memory, reasoning, attention and concentration, and visuo-spatial and verbal abilities.

Results: Compared with controls, ODM scored higher in tests for learning, long-term retrieval/storage (p = 0.008), reasoning (p = 0.02), verbal ability (p = 0.01), and attention and concentration (p = 0.003). In multiple regression, adjusted for the child’s age, sex, gestation, neonatal weight and head circumference, maternal age, parity and BMI, and the parent’s socioeconomic status, education and rural/urban residence, this difference remained significant only for learning, long-term retrieval/storage (β = 0.4 SD (95% CI 0.01–0.75); p = 0.04) and verbal ability (β = 0.5 SD (95% CI 0.09–0.83); p = 0.02), and not with other test scores.

Conclusions/interpretation: In this population of healthy Indian children, there was no evidence of lower cognitive ability in ODM. In fact some cognitive scores were higher in ODM.

Item Type: Article
ISSNs: 0012-186X (print)
1432-0428 (electronic)
Keywords: children, cognitive function, gestational diabetes mellitus, india
Subjects: R Medicine > RB Pathology
R Medicine > RG Gynecology and obstetrics
R Medicine > RJ Pediatrics > RJ101 Child Health. Child health services
Divisions: University Structure - Pre August 2011 > School of Medicine
ePrint ID: 165453
Date Deposited: 12 Oct 2010 15:22
Last Modified: 27 Mar 2014 19:18
URI: http://eprints.soton.ac.uk/id/eprint/165453

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