Childhood cognitive ability: relationship to gestational diabetes mellitus in India
Veena, S.R., Krishnaveni, G.V., Srinivasan, K., Kurpad, A.V., Muthayya, S, Hill, J.C., Kiran, K.N. and Fall, C.H. (2010) Childhood cognitive ability: relationship to gestational diabetes mellitus in India. Diabetologia, 53, (10), 2134-2138. (doi:10.1007/s00125-010-1847-0 ). (PMID:20614102).
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Aims/hypothesis: Our aim was to test the hypothesis that gestational diabetes mellitus (GDM) in mothers is associated with poorer cognitive ability in their offspring in India.
Methods: During 1997 to 1998 maternal GDM status was assessed by OGTT at 30 ± 2 weeks of gestation. Between 2007 and 2008, at a mean age of 9.7 years, 515 children (32 offspring of GDM mothers [ODM]; 483 offspring of non-GDM mothers [controls]) from the Mysore Parthenon birth cohort underwent cognitive function assessment using tests from the Kaufman Assessment Battery for Children—Second Edition and additional tests measuring learning, long-term storage/retrieval, short-term memory, reasoning, attention and concentration, and visuo-spatial and verbal abilities.
Results: Compared with controls, ODM scored higher in tests for learning, long-term retrieval/storage (p = 0.008), reasoning (p = 0.02), verbal ability (p = 0.01), and attention and concentration (p = 0.003). In multiple regression, adjusted for the child’s age, sex, gestation, neonatal weight and head circumference, maternal age, parity and BMI, and the parent’s socioeconomic status, education and rural/urban residence, this difference remained significant only for learning, long-term retrieval/storage (β = 0.4 SD (95% CI 0.01–0.75); p = 0.04) and verbal ability (β = 0.5 SD (95% CI 0.09–0.83); p = 0.02), and not with other test scores.
Conclusions/interpretation: In this population of healthy Indian children, there was no evidence of lower cognitive ability in ODM. In fact some cognitive scores were higher in ODM.
|Keywords:||children, cognitive function, gestational diabetes mellitus, india|
|Subjects:||R Medicine > RB Pathology
R Medicine > RG Gynecology and obstetrics
R Medicine > RJ Pediatrics > RJ101 Child Health. Child health services
|Divisions:||University Structure - Pre August 2011 > School of Medicine
|Date Deposited:||12 Oct 2010 15:22|
|Last Modified:||01 Jun 2011 03:19|
|Contributors:||Veena, S.R. (Author)
Krishnaveni, G.V. (Author)
Srinivasan, K. (Author)
Kurpad, A.V. (Author)
Muthayya, S (Author)
Hill, J.C. (Author)
Kiran, K.N. (Author)
Fall, C.H. (Author)
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