Hypovitaminosis D and bone mineral metabolism and bone density in hyperthyroidism
Hypovitaminosis D and bone mineral metabolism and bone density in hyperthyroidism
Little is known about the impact of concomitant vitamin D deficiency on bone mineral density in hyperthyroidism. Therefore, we evaluated bone mineral measures in vitamin D–deficient and sufficient patients with hyperthyroidism. Thirty newly diagnosed consecutive patients with hyperthyroidism were included. Blood samples were used for measurement of calcium, phosphate, alkaline phosphatase, 25-hydroxy vitamin D [25(OH) D], and parathyroid hormone (PTH). Bone mineral density (BMD) was measured at the hip, spine, and forearm. The patients were divided into vitamin D–deficient (<25 nmol/L) and vitamin D–sufficient groups (?25 nmol/L). Eight (26.6%) patients had 25(OH) D levels less than 25 nmol/L, with mean ± standard deviation (SD) level of 16.5 ± 3.2 (vitamin D–deficient group 1), and the remainder had a mean ± SD of 46.0 ± 13.5 nmol/L (vitamin D–sufficient group 2). Serum-intact PTH levels were significantly higher in group 1 compared with those in group 2 (31.2 ± 16.3 vs 18.0 ± 13.1 pg/mL; p = 0.041). In the vitamin D–deficient group, the mean BMD T-scores were in the osteoporotic range at hip and forearm (?2.65 ± 1.13 and ?3.04 ± 1.3) and in the osteopenia range at lumbar spine (?1.83 ± 1.71). However, in vitamin D–sufficient group, the mean BMD T-scores were in the osteopenia range (?1.64 ± 1.0, ?1.27 ± 1.6, and ?1.60 ± 0.7) at hip, forearm, and lumbar spine, respectively. The mean BMD Z-scores were also significantly lower in vitamin D–deficient group compared with those in vitamin D–sufficient group. Finally, BMD values (gm/cm2) at the hip and forearm were significantly lower in the vitamin D–deficient group compared with those in the vitamin D–sufficient group. In conclusion, hyperthyroid patients with concomitant vitamin D deficiency had lower BMD compared with vitamin D–sufficient patients
462-466
Dhanwal, Dinesh Kumar
54fe1b26-65da-4e44-88ec-39a93fc9e785
Kochupillai, Narayana
ba08c3e6-9f2c-4ce4-bd15-14a11c57aaeb
Gupta, Nandita
57b72023-a1c0-49c5-8b72-c8f61c20c186
Cooper, Cyrus
e05f5612-b493-4273-9b71-9e0ce32bdad6
Dennison, Elaine M.
ee647287-edb4-4392-8361-e59fd505b1d1
October 2010
Dhanwal, Dinesh Kumar
54fe1b26-65da-4e44-88ec-39a93fc9e785
Kochupillai, Narayana
ba08c3e6-9f2c-4ce4-bd15-14a11c57aaeb
Gupta, Nandita
57b72023-a1c0-49c5-8b72-c8f61c20c186
Cooper, Cyrus
e05f5612-b493-4273-9b71-9e0ce32bdad6
Dennison, Elaine M.
ee647287-edb4-4392-8361-e59fd505b1d1
Dhanwal, Dinesh Kumar, Kochupillai, Narayana, Gupta, Nandita, Cooper, Cyrus and Dennison, Elaine M.
(2010)
Hypovitaminosis D and bone mineral metabolism and bone density in hyperthyroidism.
Journal of Clinical Densitometry, 13 (4), .
(doi:10.1016/j.jocd.2010.05.008).
(PMID:20663698)
Abstract
Little is known about the impact of concomitant vitamin D deficiency on bone mineral density in hyperthyroidism. Therefore, we evaluated bone mineral measures in vitamin D–deficient and sufficient patients with hyperthyroidism. Thirty newly diagnosed consecutive patients with hyperthyroidism were included. Blood samples were used for measurement of calcium, phosphate, alkaline phosphatase, 25-hydroxy vitamin D [25(OH) D], and parathyroid hormone (PTH). Bone mineral density (BMD) was measured at the hip, spine, and forearm. The patients were divided into vitamin D–deficient (<25 nmol/L) and vitamin D–sufficient groups (?25 nmol/L). Eight (26.6%) patients had 25(OH) D levels less than 25 nmol/L, with mean ± standard deviation (SD) level of 16.5 ± 3.2 (vitamin D–deficient group 1), and the remainder had a mean ± SD of 46.0 ± 13.5 nmol/L (vitamin D–sufficient group 2). Serum-intact PTH levels were significantly higher in group 1 compared with those in group 2 (31.2 ± 16.3 vs 18.0 ± 13.1 pg/mL; p = 0.041). In the vitamin D–deficient group, the mean BMD T-scores were in the osteoporotic range at hip and forearm (?2.65 ± 1.13 and ?3.04 ± 1.3) and in the osteopenia range at lumbar spine (?1.83 ± 1.71). However, in vitamin D–sufficient group, the mean BMD T-scores were in the osteopenia range (?1.64 ± 1.0, ?1.27 ± 1.6, and ?1.60 ± 0.7) at hip, forearm, and lumbar spine, respectively. The mean BMD Z-scores were also significantly lower in vitamin D–deficient group compared with those in vitamin D–sufficient group. Finally, BMD values (gm/cm2) at the hip and forearm were significantly lower in the vitamin D–deficient group compared with those in the vitamin D–sufficient group. In conclusion, hyperthyroid patients with concomitant vitamin D deficiency had lower BMD compared with vitamin D–sufficient patients
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Published date: October 2010
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Local EPrints ID: 166817
URI: http://eprints.soton.ac.uk/id/eprint/166817
ISSN: 1094-6950
PURE UUID: 40b1f35d-45ff-4481-9356-bd6db992ac84
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Date deposited: 04 Nov 2010 09:15
Last modified: 18 Mar 2024 02:45
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Author:
Dinesh Kumar Dhanwal
Author:
Narayana Kochupillai
Author:
Nandita Gupta
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