Functional dilator capacity is independently associated with insulin sensitivity and age in central obesity but is not improved by high dose statin treatment
Clough, G.F., L'Esperance, V, Turzyniecka, M., Walter, L, Chipperfield, A.J., Gamble, J, Krentz, A.J. and Byrne, Christopher D. (2010) Functional dilator capacity is independently associated with insulin sensitivity and age in central obesity but is not improved by high dose statin treatment. Microcirculation, 18, (1), 74-84. (doi:10.1111/j.1549-8719.2010.00070.x). (PMID:21166928).
Objective: To test the hypothesis that: (i) functional microvascular dilator capacity is independently associated with insulin sensitivity and age in individuals with central adiposity at risk of cardiovascular disease (CVD); and (ii) functional microvascular dilator capacity is improved by high dose statin treatment.
Methods: Functional dilator capacity (measured as change in laser Doppler blood flux from baseline during post occlusive reactive hyperemia [peak flux%resting flux; PF%RF] and flowmotion (power spectral density [PSD] analysis)) were assessed in 40 people with central adiposity and one or more other CVD risk factors. Measurements were made at rest and during acute hyperinsulinaemia before and six months after high dose atorvastatin (40 mg daily) or placebo.
Results: Insulin-induced change in PF%RF was independently associated with insulin sensitivity (M/I) (r = 0.46 p = 0.02) and age (r = −0.46 p = 0.02), which together explained almost half of the variance in PF%RF (adjusted r2 = 0.37, p = 0.008). Whilst atorvastatin decreased LDL cholesterol by 51% (p < 0.001), PF%RF and flowmotion remained unchanged.
Conclusions: Insulin sensitivity and age are independently associated with an insulin-induced change in functional microvascular dilator capacity in individuals with central adiposity at risk of CVD. Dilator capacity is not improved by six months high dose statin treatment.
|Keywords:||central obesity, endothelium, insulin sensitivity, laser doppler fluximetry, microvasculature, skin, statins|
|Subjects:||Q Science > QP Physiology
R Medicine > R Medicine (General)
|Divisions:||University Structure - Pre August 2011 > School of Medicine > Developmental Origins of Health and Disease
|Date Deposited:||10 Nov 2010 10:06|
|Last Modified:||08 Jun 2012 12:59|
|Contributors:||Clough, G.F. (Author)
L'Esperance, V (Author)
Turzyniecka, M. (Author)
Walter, L (Author)
Chipperfield, A.J. (Author)
Gamble, J (Author)
Krentz, A.J. (Author)
Byrne, Christopher D. (Author)
|RDF:||RDF+N-Triples, RDF+N3, RDF+XML, Browse.|
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