The enhancement of contextual fear conditioning by ABT-418
Kenney, Justin W., Wilkinson, Derek S. and Gould, Thomas J. (2010) The enhancement of contextual fear conditioning by ABT-418. Behavioural Pharmacology, 21, (3), 246-9. (doi:10.1097/FBP.0b013e32833a5b9d). (PMID:20400893).
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Description/Abstract
Activation of nicotinic acetylcholine receptors (nAChRs) is known to modulate various forms of learning and memory, including contextual fear conditioning. Although numerous studies have shown that high-affinity beta2-containing nAChRs are necessary for the nicotine-induced enhancement of contextual fear conditioning, it is unknown whether other high-affinity nAChR agonists are capable of enhancing this learning. To examine this issue, ABT-418, a high-affinity nAChR agonist with greater selectivity for high-affinity receptors than nicotine, was administered before acquisition and/or recall of contextual fear memories. ABT-418 enhanced acquisition of contextual fear memories in a dose-dependent manner.
| Item Type: | Article |
|---|---|
| ISSNs: | 0955-8810 (print) 1473-5849 (electronic) |
| Subjects: | R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry R Medicine > RM Therapeutics. Pharmacology B Philosophy. Psychology. Religion > BF Psychology |
| Divisions: | University Structure - Pre August 2011 > School of Biological Sciences |
| Item ID: | 168295 |
| Date Deposited: | 30 Nov 2010 15:35 |
| Last Modified: | 01 Jun 2011 05:36 |
| Contributors: | Kenney, Justin W. (Author) Wilkinson, Derek S. (Author) Gould, Thomas J. (Author) |
| Date: | May 2010 |
| Status: | Published |
| URI: | http://eprints.soton.ac.uk/id/eprint/168295 |
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