The enhancement of contextual fear conditioning by ABT-418

Kenney, Justin W., Wilkinson, Derek S. and Gould, Thomas J. (2010) The enhancement of contextual fear conditioning by ABT-418. Behavioural Pharmacology, 21, (3), 246-9. (doi:10.1097/FBP.0b013e32833a5b9d). (PMID:20400893).


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Activation of nicotinic acetylcholine receptors (nAChRs) is known to modulate various forms of learning and memory, including contextual fear conditioning. Although numerous studies have shown that high-affinity beta2-containing nAChRs are necessary for the nicotine-induced enhancement of contextual fear conditioning, it is unknown whether other high-affinity nAChR agonists are capable of enhancing this learning. To examine this issue, ABT-418, a high-affinity nAChR agonist with greater selectivity for high-affinity receptors than nicotine, was administered before acquisition and/or recall of contextual fear memories. ABT-418 enhanced acquisition of contextual fear memories in a dose-dependent manner.

Item Type: Article
ISSNs: 0955-8810 (print)
1473-5849 (electronic)
Subjects: R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
R Medicine > RM Therapeutics. Pharmacology
B Philosophy. Psychology. Religion > BF Psychology
Divisions: University Structure - Pre August 2011 > School of Biological Sciences
ePrint ID: 168295
Date Deposited: 30 Nov 2010 15:35
Last Modified: 27 Mar 2014 19:19

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