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The enhancement of contextual fear conditioning by ABT-418

The enhancement of contextual fear conditioning by ABT-418
The enhancement of contextual fear conditioning by ABT-418
Activation of nicotinic acetylcholine receptors (nAChRs) is known to modulate various forms of learning and memory, including contextual fear conditioning. Although numerous studies have shown that high-affinity beta2-containing nAChRs are necessary for the nicotine-induced enhancement of contextual fear conditioning, it is unknown whether other high-affinity nAChR agonists are capable of enhancing this learning. To examine this issue, ABT-418, a high-affinity nAChR agonist with greater selectivity for high-affinity receptors than nicotine, was administered before acquisition and/or recall of contextual fear memories. ABT-418 enhanced acquisition of contextual fear memories in a dose-dependent manner.
0955-8810
246-9
Kenney, Justin W.
a498bbd6-750d-4778-bd72-6ea336c883e8
Wilkinson, Derek S.
6f3b2ddb-70ec-48e8-b29e-28eab85231c0
Gould, Thomas J.
de84ac91-2b6f-4524-b4d3-1f210047c57a
Kenney, Justin W.
a498bbd6-750d-4778-bd72-6ea336c883e8
Wilkinson, Derek S.
6f3b2ddb-70ec-48e8-b29e-28eab85231c0
Gould, Thomas J.
de84ac91-2b6f-4524-b4d3-1f210047c57a

Kenney, Justin W., Wilkinson, Derek S. and Gould, Thomas J. (2010) The enhancement of contextual fear conditioning by ABT-418. Behavioural Pharmacology, 21 (3), 246-9. (doi:10.1097/FBP.0b013e32833a5b9d). (PMID:20400893)

Record type: Article

Abstract

Activation of nicotinic acetylcholine receptors (nAChRs) is known to modulate various forms of learning and memory, including contextual fear conditioning. Although numerous studies have shown that high-affinity beta2-containing nAChRs are necessary for the nicotine-induced enhancement of contextual fear conditioning, it is unknown whether other high-affinity nAChR agonists are capable of enhancing this learning. To examine this issue, ABT-418, a high-affinity nAChR agonist with greater selectivity for high-affinity receptors than nicotine, was administered before acquisition and/or recall of contextual fear memories. ABT-418 enhanced acquisition of contextual fear memories in a dose-dependent manner.

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Published date: May 2010

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Local EPrints ID: 168295
URI: http://eprints.soton.ac.uk/id/eprint/168295
ISSN: 0955-8810
PURE UUID: 28e69bce-f1a7-443a-a107-587e933a931d

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Date deposited: 30 Nov 2010 15:35
Last modified: 14 Mar 2024 02:17

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Contributors

Author: Justin W. Kenney
Author: Derek S. Wilkinson
Author: Thomas J. Gould

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