The role of glia in protein misfolding diseases


Samso, Peter Benjamin (2010) The role of glia in protein misfolding diseases. University of Southampton, School of Biological Sciences, Masters Thesis , 83pp.

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Description/Abstract

The astrocytes, oligodendrocytes and microglia make up a significant proportion of the cells of the CNS. In recent years, there has been a burgeoning interest in the role of glial cells, in neurodegenerative disease. These cell types have been shown to play diverse roles in neuroinflammation, bioenergetics, signalling and intracellular oxidative balance, amongst others. Studies on Parkinson's, Alzheimer's, Huntington's and prion diseases suggest that the misfolded intra- or extra-cellular proteins that characterize these diseases could interfere with glial cell functions. I have developed and characterized an in vitro astrocyte primary cell culture. I have used this to look at the changes in glial glutamate transporter levels in the presence of mutant htt and to conduct a set of calcium experiments. These experiments provide essential tools for future studies into glial biology in neurodegeneration.

Item Type: Thesis (Masters)
Subjects: R Medicine > RB Pathology
R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
Q Science > QH Natural history > QH301 Biology
Divisions: University Structure - Pre August 2011 > School of Biological Sciences
ePrint ID: 168311
Date Deposited: 03 Dec 2010 16:08
Last Modified: 27 Mar 2014 19:19
URI: http://eprints.soton.ac.uk/id/eprint/168311

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