The role of glia in protein misfolding diseases
Samson, Ben (2010) The role of glia in protein misfolding diseases. University of Southampton, School of Biological Sciences, Masters Thesis , 83pp.
The astrocytes, oligodendrocytes and microglia make up a significant proportion of the cells of the CNS. In recent years, there has been a burgeoning interest in the role of glial cells, in neurodegenerative disease. These cell types have been shown to play diverse roles in neuroinflammation, bioenergetics, signalling and intracellular oxidative balance, amongst others. Studies on Parkinson's, Alzheimer's, Huntington's and prion diseases suggest that the misfolded intra- or extra-cellular proteins that characterize these diseases could interfere with glial cell functions. I have developed and characterized an in vitro astrocyte primary cell culture. I have used this to look at the changes in glial glutamate transporter levels in the presence of mutant htt and to conduct a set of calcium experiments. These experiments provide essential tools for future studies into glial biology in neurodegeneration.
|Item Type:||Thesis (Masters)|
|Subjects:||Q Science > QH Natural history > QH301 Biology
R Medicine > RB Pathology
R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
|Divisions:||University Structure - Pre August 2011 > School of Biological Sciences
|Date Deposited:||03 Dec 2010 16:08|
|Last Modified:||23 Jan 2015 14:33|
|RDF:||RDF+N-Triples, RDF+N3, RDF+XML, Browse.|
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