Lymphocyte sub-population cell counts are associated with the metabolic syndrome and its components in the Vietnam Experience Study
Lymphocyte sub-population cell counts are associated with the metabolic syndrome and its components in the Vietnam Experience Study
Objective: The metabolic syndrome (MetS) increases the risk of cardiovascular disease morbidity and mortality. MetS is also associated with increases in the number of circulating white blood cells. Lymphocyte sub-population counts have also been implicated in cardiovascular disease; this analysis will examine whether or not they are associated with MetS.
Methods: Participants were 4255 Vietnam-era US veterans. From military service files, telephone interviews, and a medical examination, occupational, socio-demographic, and health data were collected. MetS was ascertained from: body mass index; fasting blood glucose or a diabetes medication; blood pressure or a diagnosis of hypertension; HDL cholesterol; and triglyceride levels. Circulating T, T4, T8 and B lymphocytes cell numbers were determined by flow cytometry.
Results: In fully adjusted logistic regression analyses, high lymphocyte sub-population counts were associated with an increased risk of MetS: T cells, OR = 2.68, 95%CI 1.99–3.61, p < .001; T4 cells, OR = 2.37, 95%CI 1.78–3.15, p < .001; T8 cells, OR = 1.79, 95%CI 1.43–2.24, p < .001; B cells, OR = 1.82, 95%CI 1.51–2.19, p < .001. High lymphocyte sub-population numbers were also associated with an increased likelihood of possessing each of the MetS components, as well as the number of components possessed.
Conclusions: These results extend previous research which has largely been confined to total white blood cell or overall lymphocyte counts. If the present associations arise in prospective research, it is possible that simple lymphocyte cell counts could provide an additional prognostic indicator of risk for MetS.
b lymphocytes, t lymphocytes, metabolic syndrome
294-298
Phillips, Anna C.
d007c34d-e3b8-4a33-9608-841383e54e47
Carroll, Douglas
713a28c3-4e36-4dd8-aabe-1b5e93de8045
Gale, Catharine R.
5bb2abb3-7b53-42d6-8aa7-817e193140c8
Drayson, Mark
8327e2ee-c41a-4a4e-8ebd-fbe7016d1a10
Thomas, G.Neil
10851b1d-ee79-491d-8693-74839598f6c7
Batty, G.David
b592fe37-9757-4ea7-820b-b3d7896f9cf2
November 2010
Phillips, Anna C.
d007c34d-e3b8-4a33-9608-841383e54e47
Carroll, Douglas
713a28c3-4e36-4dd8-aabe-1b5e93de8045
Gale, Catharine R.
5bb2abb3-7b53-42d6-8aa7-817e193140c8
Drayson, Mark
8327e2ee-c41a-4a4e-8ebd-fbe7016d1a10
Thomas, G.Neil
10851b1d-ee79-491d-8693-74839598f6c7
Batty, G.David
b592fe37-9757-4ea7-820b-b3d7896f9cf2
Phillips, Anna C., Carroll, Douglas, Gale, Catharine R., Drayson, Mark, Thomas, G.Neil and Batty, G.David
(2010)
Lymphocyte sub-population cell counts are associated with the metabolic syndrome and its components in the Vietnam Experience Study.
Atherosclerosis, 213 (1), .
(doi:10.1016/j.atherosclerosis.2010.08.047).
(PMID:20833394)
Abstract
Objective: The metabolic syndrome (MetS) increases the risk of cardiovascular disease morbidity and mortality. MetS is also associated with increases in the number of circulating white blood cells. Lymphocyte sub-population counts have also been implicated in cardiovascular disease; this analysis will examine whether or not they are associated with MetS.
Methods: Participants were 4255 Vietnam-era US veterans. From military service files, telephone interviews, and a medical examination, occupational, socio-demographic, and health data were collected. MetS was ascertained from: body mass index; fasting blood glucose or a diabetes medication; blood pressure or a diagnosis of hypertension; HDL cholesterol; and triglyceride levels. Circulating T, T4, T8 and B lymphocytes cell numbers were determined by flow cytometry.
Results: In fully adjusted logistic regression analyses, high lymphocyte sub-population counts were associated with an increased risk of MetS: T cells, OR = 2.68, 95%CI 1.99–3.61, p < .001; T4 cells, OR = 2.37, 95%CI 1.78–3.15, p < .001; T8 cells, OR = 1.79, 95%CI 1.43–2.24, p < .001; B cells, OR = 1.82, 95%CI 1.51–2.19, p < .001. High lymphocyte sub-population numbers were also associated with an increased likelihood of possessing each of the MetS components, as well as the number of components possessed.
Conclusions: These results extend previous research which has largely been confined to total white blood cell or overall lymphocyte counts. If the present associations arise in prospective research, it is possible that simple lymphocyte cell counts could provide an additional prognostic indicator of risk for MetS.
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Published date: November 2010
Keywords:
b lymphocytes, t lymphocytes, metabolic syndrome
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Local EPrints ID: 170359
URI: http://eprints.soton.ac.uk/id/eprint/170359
ISSN: 0021-9150
PURE UUID: cbe608d8-ce61-4f99-8e79-3295d7eda1c8
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Date deposited: 05 Jan 2011 14:46
Last modified: 14 Mar 2024 02:38
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Author:
Anna C. Phillips
Author:
Douglas Carroll
Author:
Mark Drayson
Author:
G.Neil Thomas
Author:
G.David Batty
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