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The relationship between infant lung function and the risk of wheeze in the preschool years

The relationship between infant lung function and the risk of wheeze in the preschool years
The relationship between infant lung function and the risk of wheeze in the preschool years
Rationale: There is evidence that perinatal lung development predicts childhood wheeze. However, very few studies have examined whether preschool wheeze is associated with lower premorbid lung function in early infancy, and as yet there is no information relating atopic and non-atopic preschool wheeze to early lung development.
Objective: To examine the association between premorbid infant lung function and preschool wheeze, and to explore associations with atopic and non-atopic wheeze phenotypes.

Methods: Infant lung function was measured in 147 healthy term infants aged 5–14 weeks. Rapid thoracoabdominal compression was performed during tidal breathing and at raised volume to measure maximal expiratory flow at functional residual capacity and forced expiratory volume in 0.4?sec (FEV0.4). Atopic status was determined by skin prick testing at 3 years and wheeze ascertained from parental questionnaires (1 and 3 years).

Measurements and Main Results: Lower early infancy was associated with wheeze in both the first and third years of life (P?=?0.002 and 0.006, respectively). Lower early infancy FEV0.4 was associated with wheeze in the first year (P?=?0.03). Compared to non-atopic children who did not wheeze, non-atopic children who wheezed in their third year of life had lower FEV0.4 (P?=?0.02), while FEV0.4 values of atopic children who wheezed were not significantly different (P?=?0.4).

Conclusions: Lower premorbid infant lung function was present in infants who subsequently wheezed during the first and third years of life. Lower FEV0.4 in early infancy was associated with non-atopic wheeze but not atopic wheeze at 3 years of age.
wheeze, asthma, infant lung function, preschool
8755-6863
75-82
Pike, K.C.
10be90c8-73de-416e-a2d0-0bb7e7276bd3
Rose-Zerilli, M.J.
08b3afa4-dbc2-4c0d-a852-2a9f33431199
Osvald, E. Caffrey
e66cdc17-2e53-4b66-a14e-69ea6dba0f23
Inskip, H.M.
5fb4470a-9379-49b2-a533-9da8e61058b7
Godfrey, K.M.
0931701e-fe2c-44b5-8f0d-ec5c7477a6fd
Crozier, S.R.
a97b1967-f6af-413a-8eb0-69fa25534d68
Roberts, G.
1a20cab3-ea1a-403a-8b15-1068bf2e52cb
Clough, J.B.
54c3712a-f495-4ba6-b190-73fa0ba2b30f
Holloway, J.W.
4bbd77e6-c095-445d-a36b-a50a72f6fe1a
Lucas, J.S.
5cb3546c-87b2-4e59-af48-402076e25313
Pike, K.C.
10be90c8-73de-416e-a2d0-0bb7e7276bd3
Rose-Zerilli, M.J.
08b3afa4-dbc2-4c0d-a852-2a9f33431199
Osvald, E. Caffrey
e66cdc17-2e53-4b66-a14e-69ea6dba0f23
Inskip, H.M.
5fb4470a-9379-49b2-a533-9da8e61058b7
Godfrey, K.M.
0931701e-fe2c-44b5-8f0d-ec5c7477a6fd
Crozier, S.R.
a97b1967-f6af-413a-8eb0-69fa25534d68
Roberts, G.
1a20cab3-ea1a-403a-8b15-1068bf2e52cb
Clough, J.B.
54c3712a-f495-4ba6-b190-73fa0ba2b30f
Holloway, J.W.
4bbd77e6-c095-445d-a36b-a50a72f6fe1a
Lucas, J.S.
5cb3546c-87b2-4e59-af48-402076e25313

Pike, K.C., Rose-Zerilli, M.J., Osvald, E. Caffrey, Inskip, H.M., Godfrey, K.M., Crozier, S.R., Roberts, G., Clough, J.B., Holloway, J.W. and Lucas, J.S. (2011) The relationship between infant lung function and the risk of wheeze in the preschool years. Pediatric Pulmonology, 46 (1), 75-82. (doi:10.1002/ppul.21327). (PMID:20848581)

Record type: Article

Abstract

Rationale: There is evidence that perinatal lung development predicts childhood wheeze. However, very few studies have examined whether preschool wheeze is associated with lower premorbid lung function in early infancy, and as yet there is no information relating atopic and non-atopic preschool wheeze to early lung development.
Objective: To examine the association between premorbid infant lung function and preschool wheeze, and to explore associations with atopic and non-atopic wheeze phenotypes.

Methods: Infant lung function was measured in 147 healthy term infants aged 5–14 weeks. Rapid thoracoabdominal compression was performed during tidal breathing and at raised volume to measure maximal expiratory flow at functional residual capacity and forced expiratory volume in 0.4?sec (FEV0.4). Atopic status was determined by skin prick testing at 3 years and wheeze ascertained from parental questionnaires (1 and 3 years).

Measurements and Main Results: Lower early infancy was associated with wheeze in both the first and third years of life (P?=?0.002 and 0.006, respectively). Lower early infancy FEV0.4 was associated with wheeze in the first year (P?=?0.03). Compared to non-atopic children who did not wheeze, non-atopic children who wheezed in their third year of life had lower FEV0.4 (P?=?0.02), while FEV0.4 values of atopic children who wheezed were not significantly different (P?=?0.4).

Conclusions: Lower premorbid infant lung function was present in infants who subsequently wheezed during the first and third years of life. Lower FEV0.4 in early infancy was associated with non-atopic wheeze but not atopic wheeze at 3 years of age.

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More information

Accepted/In Press date: 16 September 2010
Published date: January 2011
Keywords: wheeze, asthma, infant lung function, preschool

Identifiers

Local EPrints ID: 170767
URI: http://eprints.soton.ac.uk/id/eprint/170767
ISSN: 8755-6863
PURE UUID: 312ac034-e54c-46f9-87e1-c2853feb40b5
ORCID for M.J. Rose-Zerilli: ORCID iD orcid.org/0000-0002-1064-5350
ORCID for H.M. Inskip: ORCID iD orcid.org/0000-0001-8897-1749
ORCID for K.M. Godfrey: ORCID iD orcid.org/0000-0002-4643-0618
ORCID for J.W. Holloway: ORCID iD orcid.org/0000-0001-9998-0464
ORCID for J.S. Lucas: ORCID iD orcid.org/0000-0001-8701-9975

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Date deposited: 04 Feb 2011 09:38
Last modified: 14 Mar 2024 02:56

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Contributors

Author: K.C. Pike
Author: E. Caffrey Osvald
Author: H.M. Inskip ORCID iD
Author: K.M. Godfrey ORCID iD
Author: S.R. Crozier
Author: G. Roberts
Author: J.B. Clough
Author: J.W. Holloway ORCID iD
Author: J.S. Lucas ORCID iD

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