Sarcoidosis presenting with an acute Guillain-Barre syndrome

Miller, R, Sheron, Nick and Semple, S (1989) Sarcoidosis presenting with an acute Guillain-Barre syndrome. Postgraduate Medical Journal, 65, 765-767. (doi:10.1136/pgmj.65.768.765). (PMID:2694139).


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A 28 year old Caucasian male presented with an acute Guillain-Barré syndrome and bilateral facial weakness. He had an abnormal chest radiograph. Lumbar puncture revealed acellular fluid with a raised protein count and lung function tests showed a restrictive ventilatory defect. The patient deteriorated and required mechanical ventilation for 14 days. Steroids and plasmapheresis were not used and the patient spontaneously recovered. Two months after presentation limb power was almost normal but there was residual partial bilateral facial weakness. The chest radiograph remained abnormal and repeat lung function tests showed a persistent restrictive ventilatory defect and a reduced gas transfer coefficient. A transbronchial biopsy revealed non-caseating granulomata. The association between neurosarcoidosis and Guillain-Barré polyneuropathy is discussed and the literature reviewed.

Item Type: Article
Digital Object Identifier (DOI): doi:10.1136/pgmj.65.768.765
ISSNs: 0032-5473 (print)
1469-0756 (electronic)
Subjects: R Medicine > RB Pathology
R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
Divisions : University Structure - Pre August 2011 > School of Medicine > Infection, Inflammation and Repair
ePrint ID: 172305
Accepted Date and Publication Date:
October 1989Published
Date Deposited: 25 Jan 2011 11:42
Last Modified: 31 Mar 2016 13:32

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