Chapter 78 - The placental role in fetal programming
Lewis, Rohan M., Cleal, Jane K. and Godfrey, Keith M. (2011) Chapter 78 - The placental role in fetal programming. In, Gupta, Ramesh C. (ed.) Reproductive and Developmental Toxicology. Cambridge, GB, Elsevier, 1039-1049. (doi:10.1016/B978-0-12-382032-7.10078-5).
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The principal roles of the placenta are to protect the fetus from harmful substances while actively ensuring appropriate transfer of the nutrients essential for optimal fetal growth and development. Failure of the placenta to protect or nourish the fetus can have significant consequences for the offspring both before birth and throughout its postnatal life. Poor fetal growth is associated with increased risk of many common chronic disorders in adult life, including coronary heart disease, diabetes and some forms of cancer. These long-term consequences have been referred to as “fetal programming”. The placenta is the interface between the mother and the fetus, influencing both the intrauterine environment and fetal growth, and placental function is therefore likely to be a major determinant of programming effects. Understanding the role of the placenta in fetal programming may provide new avenues for prevention and treatment of at-risk individuals.
|Item Type:||Book Section|
|Digital Object Identifier (DOI):||doi:10.1016/B978-0-12-382032-7.10078-5|
|Subjects:||R Medicine > RB Pathology
R Medicine > RG Gynecology and obstetrics
|Divisions:||University Structure - Pre August 2011 > School of Medicine
|Date Deposited:||23 Mar 2011 11:34|
|Last Modified:||27 Mar 2014 19:21|
|RDF:||RDF+N-Triples, RDF+N3, RDF+XML, Browse.|
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