Patterns of fetal and infant growth are related to atopy and wheezing disorders at age 3 years
Patterns of fetal and infant growth are related to atopy and wheezing disorders at age 3 years
Background: Little is known about whether patterns of early growth are associated with altered respiratory and immune development. This study relates prenatal and infant growth patterns to wheeze and atopy at age 3 years.
Methods: Birth weight and length were measured in 1548 children born at term. Conditional fetal head and abdominal circumference growth velocities were calculated from antenatal ultrasound measurements. Conditional postnatal growth velocities were calculated from infant weight, length and adiposity data. Measures of size and conditional growth were related to parentally-reported infant and early childhood wheeze and to atopic status at age 3 years.
Results: The risk of atopy increased by 46% per SD increase in abdominal circumference growth velocity from 11 to 19 weeks gestation but by 20% per SD decrease in abdominal growth velocity from 19 to 34 weeks (p=0.007 and p=0.011, respectively). The risk of atopic wheeze increased by 20% per SD decrease in 19–34-week abdominal growth (p=0.046). The risk of non-atopic wheeze increased by 10% per SD decrease in 11–19-week head circumference growth. Greater relative infant weight and adiposity gains were associated with both atopic and non-atopic wheeze.
Conclusions: A rapid growth trajectory during 11–19 weeks gestation followed by late gestation growth faltering is associated with atopy, suggesting that influences affecting fetal growth may also alter immune development. A lower early fetal growth trajectory is associated with non-atopic wheeze, possibly reflecting an association with smaller airways. An association between postnatal adiposity gain and wheeze may partly reflect prenatal influences that cause fetal growth to falter but are then followed by postnatal adiposity gain.
1099-106
Pike, Katharine P.
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Crozier, Sarah R.
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Lucas, Jane S.A.
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Inskip, Hazel M.
5fb4470a-9379-49b2-a533-9da8e61058b7
Robinson, Sian
ba591c98-4380-456a-be8a-c452f992b69b
Roberts, Graham
ea00db4e-84e7-4b39-8273-9b71dbd7e2f3
Godfrey, Keith M.
0931701e-fe2c-44b5-8f0d-ec5c7477a6fd
Southampton Women's Survey Study Group
December 2010
Pike, Katharine P.
10be90c8-73de-416e-a2d0-0bb7e7276bd3
Crozier, Sarah R.
f725a749-98a7-47ba-aa6b-8d8e17c72cad
Lucas, Jane S.A.
5cb3546c-87b2-4e59-af48-402076e25313
Inskip, Hazel M.
5fb4470a-9379-49b2-a533-9da8e61058b7
Robinson, Sian
ba591c98-4380-456a-be8a-c452f992b69b
Roberts, Graham
ea00db4e-84e7-4b39-8273-9b71dbd7e2f3
Godfrey, Keith M.
0931701e-fe2c-44b5-8f0d-ec5c7477a6fd
Pike, Katharine P., Crozier, Sarah R., Lucas, Jane S.A., Inskip, Hazel M., Robinson, Sian, Roberts, Graham and Godfrey, Keith M.
,
Southampton Women's Survey Study Group
(2010)
Patterns of fetal and infant growth are related to atopy and wheezing disorders at age 3 years.
Thorax, 65 (12), .
(doi:10.1136/thx.2010.134742).
(PMID:20956394)
Abstract
Background: Little is known about whether patterns of early growth are associated with altered respiratory and immune development. This study relates prenatal and infant growth patterns to wheeze and atopy at age 3 years.
Methods: Birth weight and length were measured in 1548 children born at term. Conditional fetal head and abdominal circumference growth velocities were calculated from antenatal ultrasound measurements. Conditional postnatal growth velocities were calculated from infant weight, length and adiposity data. Measures of size and conditional growth were related to parentally-reported infant and early childhood wheeze and to atopic status at age 3 years.
Results: The risk of atopy increased by 46% per SD increase in abdominal circumference growth velocity from 11 to 19 weeks gestation but by 20% per SD decrease in abdominal growth velocity from 19 to 34 weeks (p=0.007 and p=0.011, respectively). The risk of atopic wheeze increased by 20% per SD decrease in 19–34-week abdominal growth (p=0.046). The risk of non-atopic wheeze increased by 10% per SD decrease in 11–19-week head circumference growth. Greater relative infant weight and adiposity gains were associated with both atopic and non-atopic wheeze.
Conclusions: A rapid growth trajectory during 11–19 weeks gestation followed by late gestation growth faltering is associated with atopy, suggesting that influences affecting fetal growth may also alter immune development. A lower early fetal growth trajectory is associated with non-atopic wheeze, possibly reflecting an association with smaller airways. An association between postnatal adiposity gain and wheeze may partly reflect prenatal influences that cause fetal growth to falter but are then followed by postnatal adiposity gain.
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Published date: December 2010
Organisations:
Infection Inflammation & Immunity
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Local EPrints ID: 173517
URI: http://eprints.soton.ac.uk/id/eprint/173517
ISSN: 0040-6376
PURE UUID: ca9114c1-9e1d-496f-a292-8c42478e3742
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Date deposited: 07 Feb 2011 09:57
Last modified: 14 Mar 2024 02:50
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Author:
Katharine P. Pike
Author:
Sarah R. Crozier
Author:
Sian Robinson
Corporate Author: Southampton Women's Survey Study Group
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