The developmental origins, mechanisms, and implications of metabolic syndrome


Bruce, KD and Hanson, Mark A. (2010) The developmental origins, mechanisms, and implications of metabolic syndrome. Journal of Nutrition, 140, (3), 648-652. (doi:10.3945/​jn.109.111179). (PMID:20107145).

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Description/Abstract

Metabolic syndrome (MetS) represents a combination of cardio-metabolic risk determinants, including central obesity, insulin resistance, glucose intolerance, dyslipidemia, hypertension, hyperinsulinemia, and microalbuminuria. The prevalence of MetS is rapidly increasing worldwide, largely as a consequence of the ongoing obesity epidemic. Environmental factors during periods early in development have been shown to influence the susceptibility to develop disease in later life. In particular, there is a wealth of evidence from both epidemiological and animal studies for greater incidence of features of MetS as a result of unbalanced maternal nutrition. The mechanisms by which nutritional insults during a period of developmental plasticity result in a MetS phenotype are now beginning to receive considerable scientific interest. This review focuses on recent data regarding these mechanisms, in particular the epigenetic and transcriptional regulation of key metabolic genes in response to nutritional stimuli that mediate persistent changes and an adult MetS phenotype. A continued and greater understanding of these mechanisms will eventually allow specific interventions, with a favorable impact on the global incidence of cardiovascular disease and type 2 diabetes in the future.

Item Type: Article
ISSNs: 0022-3166 (print)
1541-6100 (electronic)
Subjects: Q Science > QR Microbiology > QR180 Immunology
R Medicine > RG Gynecology and obstetrics
R Medicine > RJ Pediatrics
Divisions: University Structure - Pre August 2011 > School of Medicine > Developmental Origins of Health and Disease
ePrint ID: 174977
Date Deposited: 18 Feb 2011 14:49
Last Modified: 27 Mar 2014 19:21
URI: http://eprints.soton.ac.uk/id/eprint/174977

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