Frequency and phenotype of circulating Valpha24/Vbeta11 double-positive natural killer T cells during hepatitis C virus infection


Lucas, Michaela, Gadola, Stephan, Meier, Ute, Young, Neil T., Harcourt, Gillian, Karadimitris, Anastasios, Coumi, Nikki, Brown, Dave, Dusheiko, Geoff, Cerundolo, Vincenzo and Klenerman, Paul (2003) Frequency and phenotype of circulating Valpha24/Vbeta11 double-positive natural killer T cells during hepatitis C virus infection. Journal of Virology, 77, (3), 2251-2257. (doi:10.1128/JVI.77.3.2251-2257.2003). (PMID:12525661).

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Description/Abstract

Natural killer T (NKT) cells are thought to be involved in innate responses against infection. We investigated one specific type of NKT cell, V24/Vß11 double positive, in hepatitis C virus (HCV) infection. Lower frequencies of this population were detected in the blood of HCV PCR-positive patients than in controls. Unlike V24/Vß11 NKT cells found in blood, those in the liver appeared to be recently activated.

Item Type: Article
ISSNs: 0022-538X (print)
1070-6321 (electronic)
Subjects: Q Science > QR Microbiology > QR180 Immunology
Q Science > QR Microbiology > QR355 Virology
R Medicine > RB Pathology
Divisions: University Structure - Pre August 2011 > School of Medicine > Infection, Inflammation and Repair
ePrint ID: 175435
Date Deposited: 23 Feb 2011 14:25
Last Modified: 27 Mar 2014 19:21
URI: http://eprints.soton.ac.uk/id/eprint/175435

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