Identification of a TAP-independent, immunoproteasome-dependent CD8+ T-cell epitope in Epstein-Barr virus latent membrane protein 2
Lautscham, Georg, Haigh, Tracey, Mayrhofer, Sabine, Taylor, Graham, Croom-Carter, Debbie, Leese, Alison, Gadola, Stephan, Cerundolo, Vincenzo, Rickinson, Alan and Blake, Neil (2003) Identification of a TAP-independent, immunoproteasome-dependent CD8+ T-cell epitope in Epstein-Barr virus latent membrane protein 2. Journal of Virology, 77, (4), 2757-2761. (doi:10.1128/JVI.77.4.2757-2761.2003). (PMID:12552018).
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Description/Abstract
We have identified an HLA-A2-restricted CD8+ T-cell epitope, FLYALALLL, in the Epstein-Barr virus (EBV) latent membrane protein 2 (LMP2), an important target antigen in the context of EBV-associated malignancies. This epitope is TAP independent, like other hydrophobic LMP2-derived epitopes, but uniquely is dependent upon the immunoproteasome for its generation.
| Item Type: | Article |
|---|---|
| ISSNs: | 0022-538X (print) 1070-6321 (electronic) |
| Subjects: | Q Science > QR Microbiology > QR180 Immunology Q Science > QR Microbiology > QR355 Virology R Medicine > RB Pathology |
| Divisions: | University Structure - Pre August 2011 > School of Medicine > Infection, Inflammation and Repair |
| Item ID: | 175469 |
| Date Deposited: | 23 Feb 2011 15:25 |
| Last Modified: | 01 Jun 2011 05:50 |
| Contributors: | Lautscham, Georg (Author) Haigh, Tracey (Author) Mayrhofer, Sabine (Author) Taylor, Graham (Author) Croom-Carter, Debbie (Author) Leese, Alison (Author) Gadola, Stephan (Author) Cerundolo, Vincenzo (Author) Rickinson, Alan (Author) Blake, Neil (Author) |
| Date: | February 2003 |
| Status: | Published |
| URI: | http://eprints.soton.ac.uk/id/eprint/175469 |
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