Surface expression of HLA-E, an inhibitor of natural killer cells, enhanced by human cytomegalovirus gpUL40
Tomasec, Peter, Braud, Veronique M., Rickards, Carole, Powell, Martin B., McSharry, Brain P., Gadola, Stephan, Cerundolo, Vincenzo, Borysiewicz, Leszek K., McMichael, Andrew J. and Wilkinson, Gavin W.G. (2000) Surface expression of HLA-E, an inhibitor of natural killer cells, enhanced by human cytomegalovirus gpUL40. Science, 287, (5455), 1031-1033. (doi:10.1126/science.287.5455.1031). (PMID:10669413).
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The nonclassical major histocompatibility complex (MHC) class I molecule HLA-E inhibits natural killer (NK) cell–mediated lysis by interacting with CD94/NKG2A receptors. Surface expression of HLA-E depends on binding of conserved peptides derived from MHC class I molecules. The same peptide is present in the leader sequence of the human cytomegalovirus (HCMV) glycoprotein UL40 (gpUL40). It is shown that, independently of the transporter associated with antigen processing, gpUL40 can up-regulate expression of HLA-E, which protects targets from NK cell lysis. While classical MHC class I molecules are down-regulated, HLA-E is up-regulated by HCMV. Induction of HLA-E surface expression by gpUL40 may represent an escape route for HCMV.
|Digital Object Identifier (DOI):||doi:10.1126/science.287.5455.1031|
|Subjects:||Q Science > QR Microbiology > QR180 Immunology
Q Science > QR Microbiology > QR355 Virology
R Medicine > RB Pathology
|Divisions:||University Structure - Pre August 2011 > School of Medicine > Infection, Inflammation and Repair
|Date Deposited:||23 Feb 2011 15:31|
|Last Modified:||27 Mar 2014 19:21|
|RDF:||RDF+N-Triples, RDF+N3, RDF+XML, Browse.|
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