Skeletal stem cells and bone regeneration: translational strategies from bench to clinic
Skeletal stem cells and bone regeneration: translational strategies from bench to clinic
Clinical imperatives for new bone to replace or restore the function of traumatized or bone lost as a consequence of age or disease has led to the need for therapies or procedures to generate bone for skeletal applications. Tissue regeneration promises to deliver specifiable replacement tissues and the prospect of efficacious alternative therapies for orthopaedic applications such as non-union fractures, healing of critical sized segmental defects and regeneration of articular cartilage in degenerative joint diseases. In this paper we review the current understanding of the continuum of cell development from skeletal stem cells, osteoprogenitors through to mature osteoblasts and the role of the matrix microenvironment, vasculature and factors that control their fate and plasticity in skeletal regeneration. Critically, this review addresses in vitro and in vivo models to investigate laboratory and clinical based strategies for the development of new technologies for skeletal repair and the key translational points to clinical success. The application of developmental paradigms of musculoskeletal tissue formation specifically, understanding developmental biology of bone formation particularly in the adult context of injury and disease will, we propose, offer new insights into skeletal cell biology and tissue regeneration allowing for the critical integration of stem cell science, tissue engineering and clinical applications. Such interdisciplinary, iterative approaches will be critical in taking patient aspirations to clinical reality.
skeletal stem cell, osteogenesis, translational research, angiogenesis, tissue regeneration, osteoprogenitor
1455-1470
Tare, R.S.
587c9db4-e409-4e7c-a02a-677547ab724a
Kanczler, J.
eb8db9ff-a038-475f-9030-48eef2b0559c
Aarvold, A.
cdb23726-6d5e-444a-979a-71ca7af83e3f
Jones, A.M.H.
ed691057-0714-4466-a207-79ed730c173c
Dunlop, D.G.
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Oreffo, R.O.C.
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December 2010
Tare, R.S.
587c9db4-e409-4e7c-a02a-677547ab724a
Kanczler, J.
eb8db9ff-a038-475f-9030-48eef2b0559c
Aarvold, A.
cdb23726-6d5e-444a-979a-71ca7af83e3f
Jones, A.M.H.
ed691057-0714-4466-a207-79ed730c173c
Dunlop, D.G.
5f8d8b5c-e516-48b8-831f-c6e5529a52cc
Oreffo, R.O.C.
ff9fff72-6855-4d0f-bfb2-311d0e8f3778
Tare, R.S., Kanczler, J., Aarvold, A., Jones, A.M.H., Dunlop, D.G. and Oreffo, R.O.C.
(2010)
Skeletal stem cells and bone regeneration: translational strategies from bench to clinic.
Proceedings of the Institution of Mechanical Engineers, Part H: Journal of Engineering in Medicine, 224 (12), .
(doi:10.1243/09544119JEIM750).
(PMID:21287831)
Abstract
Clinical imperatives for new bone to replace or restore the function of traumatized or bone lost as a consequence of age or disease has led to the need for therapies or procedures to generate bone for skeletal applications. Tissue regeneration promises to deliver specifiable replacement tissues and the prospect of efficacious alternative therapies for orthopaedic applications such as non-union fractures, healing of critical sized segmental defects and regeneration of articular cartilage in degenerative joint diseases. In this paper we review the current understanding of the continuum of cell development from skeletal stem cells, osteoprogenitors through to mature osteoblasts and the role of the matrix microenvironment, vasculature and factors that control their fate and plasticity in skeletal regeneration. Critically, this review addresses in vitro and in vivo models to investigate laboratory and clinical based strategies for the development of new technologies for skeletal repair and the key translational points to clinical success. The application of developmental paradigms of musculoskeletal tissue formation specifically, understanding developmental biology of bone formation particularly in the adult context of injury and disease will, we propose, offer new insights into skeletal cell biology and tissue regeneration allowing for the critical integration of stem cell science, tissue engineering and clinical applications. Such interdisciplinary, iterative approaches will be critical in taking patient aspirations to clinical reality.
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Published date: December 2010
Keywords:
skeletal stem cell, osteogenesis, translational research, angiogenesis, tissue regeneration, osteoprogenitor
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Local EPrints ID: 175571
URI: http://eprints.soton.ac.uk/id/eprint/175571
ISSN: 0954-4119
PURE UUID: 1b5cf6b2-f97e-43b3-b2f0-85e3369570d0
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Date deposited: 24 Feb 2011 11:32
Last modified: 14 Mar 2024 02:50
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Author:
J. Kanczler
Author:
A. Aarvold
Author:
A.M.H. Jones
Author:
D.G. Dunlop
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