A UK-based cost-utility analysis of radiofrequency ablation or oesophagectomy for the management of high-grade dysplasia in Barrett's oesophagus
Boger, P.C., Turner, D., Roderick, P. and Patel, Praful (2010) A UK-based cost-utility analysis of radiofrequency ablation or oesophagectomy for the management of high-grade dysplasia in Barrett's oesophagus. Alimentary Pharmacology and Therapeutics, 32, (11-12), 1332-1342. (doi:10.1111/j.1365-2036.2010.04450.x).
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Description/Abstract
Background
In the UK, oesophagectomy is the current recommendation for patients with persistent high-grade dysplasia in Barrett’s oesophagus. Radiofrequency ablation is an alternative new technology with promising early trial results.
Aim
To undertake a cost–utility analysis comparing these two strategies.
Methods
We constructed a Markov model to simulate the natural history of a cohort of patients with high-grade dysplasia in Barrett’s oesophagus undergoing one of two treatment options: (i) oesophagectomy or (ii) radiofrequency
ablation followed by endoscopic surveillance with oesophagectomy for high-grade dysplasia recurrence or persistence.
Results
In the base case analysis, radiofrequency ablation dominated as it generated 0.4 extra quality of life years at a cost saving of £1902. For oesophagectomy
to be the most cost-effective option, it required a radiofrequency ablation treatment failure rate (high-grade dysplasia persistence or progression to cancer) of >44%, or an annual risk of high-grade dysplasia recurrence or
progression to cancer in the ablated oesophagus of >15% per annum. There was an 85% probability that radiofrequency ablation remained cost-effective at the NICE willingness to pay threshold range of £20 000–30 000.
Conclusion
Radiofrequency ablation is likely to be a cost-effective option for high-grade dysplasia in Barrett’s oesophagus in the UK.
| Item Type: | Article |
|---|---|
| ISSNs: | 0269-2813 (print) 1365-2036 (electronic) |
| Related URLs: | |
| Subjects: | R Medicine > R Medicine (General) R Medicine > RD Surgery |
| Divisions: | University Structure - Pre August 2011 > School of Medicine > Community Clinical Sciences |
| Item ID: | 175657 |
| Date Deposited: | 25 Feb 2011 10:23 |
| Last Modified: | 01 Jun 2011 10:22 |
| Contributors: | Boger, P.C. (Author) Turner, D. (Author) Roderick, P. (Author) Patel, Praful (Author) |
| Date: | December 2010 |
| Status: | Published |
| URI: | http://eprints.soton.ac.uk/id/eprint/175657 |
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