Phosphoinositide 3-kinases and regulation of embryonic stem cell fate

Welham, M.J., Storm, M.P., Kingham, E. and Bone, H.K. (2007) Phosphoinositide 3-kinases and regulation of embryonic stem cell fate. Biochemical Society Transactions, 35, (2), 225-228. (PMID:17371244).


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ES (embryonic stem) cell lines are derived from the epiblast of pre-implantation embryos and like the inner cell mass cells from which they are derived exhibit the remarkable property of pluripotency, namely the ability to differentiate into all cell lineages comprising the adult organism. ES cells and their differentiated progeny offer tremendous potential to regenerative medicine, particularly as cellular therapies for the treatment of a wide variety of chronic disorders, such as Type 1 diabetes, Parkinson's disease and retinal degeneration. In order for this potential to be realized, a detailed understanding of the molecular mechanisms regulating the fundamental properties of ES cells, i.e. pluripotency, proliferation and differentiation, is required. In the present paper, we review the evidence that PI3K (phosphoinositide 3-kinase)-dependent signalling plays a role in regulation of both ES cell pluripotency and proliferation.

Item Type: Article
ISSNs: 0300-5127 (print)
1470-8752 (electronic)
Related URLs:
Keywords: bone morphogenetic protein (bmp), embryonic stem cell (es cell), phosphoinositide 3-kinase (pi3k), pluripotency, self-renewal
Subjects: Q Science > QH Natural history > QH301 Biology
Q Science > QR Microbiology > QR180 Immunology
R Medicine > R Medicine (General)
Divisions : University Structure - Pre August 2011 > Other
ePrint ID: 176441
Accepted Date and Publication Date:
April 2007Published
Date Deposited: 07 Mar 2011 16:43
Last Modified: 31 Mar 2016 13:33

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