Multistep DNA-templated reactions for the synthesis of functional sequence controlled oligomers
McKee, Mireya L., Milnes, Phillip J., Bath, Jonathan, Stulz, Eugen, Turberfield, Andrew J. and O'Reilly, Rachel K. (2010) Multistep DNA-templated reactions for the synthesis of functional sequence controlled oligomers. Angewandte Chemie International Edition, 49, (43), 7948-7951. (doi:10.1002/anie.201002721).
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Description/Abstract
Biomimetic: A strand displacement mechanism was designed to permit DNA-templated synthesis of functional oligomers of arbitrary length (see scheme). Key features of the mechanism are that successive coupling reactions take place in near-identical environments and that purification is only necessary in the last synthesis step.
| Item Type: | Article |
|---|---|
| ISSNs: | 1433-7851 (print) 1521-3773 (electronic) |
| Keywords: | biomimetic synthesis, dna, oligomers, template synthesis, wittig reaction |
| Subjects: | Q Science > QD Chemistry Q Science > QH Natural history > QH426 Genetics R Medicine > R Medicine (General) |
| Divisions: | University Structure - Pre August 2011 > School of Chemistry |
| Item ID: | 176843 |
| Date Deposited: | 11 Mar 2011 11:56 |
| Last Modified: | 01 Jun 2011 17:45 |
| Contributors: | McKee, Mireya L. (Author) Milnes, Phillip J. (Author) Bath, Jonathan (Author) Stulz, Eugen (Author) Turberfield, Andrew J. (Author) O'Reilly, Rachel K. (Author) |
| Date: | 18 October 2010 |
| Status: | Published |
| URI: | http://eprints.soton.ac.uk/id/eprint/176843 |
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