Osteogenesis on surface selective laser sintered bioresorbable scaffolds
Bagratashvili, Victor, Antonov, E.N., Howdle, S.M., Kanczler, J.M., Mirmalek-Sani, S., Popov, V.K., Oreffo, R.O. and Upton, C., Katashev, Alexei, Dekhtyar, Yuri and Spigulis, Janis (eds.) (2008) Osteogenesis on surface selective laser sintered bioresorbable scaffolds. 14th nordic-baltic conference on biomedical engineering and medical physics, 20, (2), 12-15. (doi:10.1007/978-3-540-69367-3_4)
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Description/Abstract
In this study we have used a novel surface selective laser sintering (SSLS) technique to develop CAD/CAM designed scaffolds for bone tissue engineering. SSLS polylactic acid scaffolds were evaluated in vitro and in vivo as templates for human fetal femur-derived cell and adult human bone marrow stromal cell osteogenesis. Both cell types were cultured successfully on SSLS scaffolds with an increase in expression of alkaline phosphatase activity. Cell in-growth and Alcian blue/Sirius red positive staining of matrix deposition were observed on SSLS scaffolds in vitro in basal medium and osteogenic culture conditions. Similar results were observed in vivo with type I collagen expressed by cells on the scaffolds. In the critical sized femur segmental defect, SSLS scaffolds seeded with the cells enhanced significantly bone tissue regeneration
| Item Type: | Article |
|---|---|
| Subjects: | R Medicine > R Medicine (General) |
| Divisions: | University Structure - Pre August 2011 > School of Medicine > Developmental Origins of Health and Disease |
| ePrint ID: | 176999 |
| URI: | http://eprints.soton.ac.uk/id/eprint/176999 |
| Deposited On: | 14 Mar 2011 08:47 |
| Last Modified: | 02 Mar 2012 13:15 |
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