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Xanthine oxidase is a peroxynitrite synthase: newly identified roles for a very old enzyme

Xanthine oxidase is a peroxynitrite synthase: newly identified roles for a very old enzyme
Xanthine oxidase is a peroxynitrite synthase: newly identified roles for a very old enzyme
Xanthine oxidase (XO) was first identified in 1902 by the German scientist Schardinger in bovine milk by following the hydroxylation of hypoxanthine to xanthine. Following this first discovery, the history of xanthine oxidase has followed the usual routes of investigation such as they were at the start of the 20th century. The electron donors and acceptors were identified and the constituents of the active sites were deduced. It turns out to be a classic, multicentred, redox enzyme. &more...
1351-0002
65-70
Millar, Timothy
ec88510c-ad88-49f6-8b2d-4277c84c1958
Kanczler, Janos
eb8db9ff-a038-475f-9030-48eef2b0559c
Bodamyali, Tulin
891aa0d1-20cd-4288-8c2c-5b369a00cf83
Blake, David
5e04d75b-8132-44fd-9565-114e1d604484
Stevens, Cliff
79241000-6e42-43e3-b005-7c369cc7c7e6
Millar, Timothy
ec88510c-ad88-49f6-8b2d-4277c84c1958
Kanczler, Janos
eb8db9ff-a038-475f-9030-48eef2b0559c
Bodamyali, Tulin
891aa0d1-20cd-4288-8c2c-5b369a00cf83
Blake, David
5e04d75b-8132-44fd-9565-114e1d604484
Stevens, Cliff
79241000-6e42-43e3-b005-7c369cc7c7e6

Millar, Timothy, Kanczler, Janos, Bodamyali, Tulin, Blake, David and Stevens, Cliff (2002) Xanthine oxidase is a peroxynitrite synthase: newly identified roles for a very old enzyme. Redox Report, 7 (2), 65-70. (doi:10.1179/135100002125000280). (PMID:12189051)

Record type: Article

Abstract

Xanthine oxidase (XO) was first identified in 1902 by the German scientist Schardinger in bovine milk by following the hydroxylation of hypoxanthine to xanthine. Following this first discovery, the history of xanthine oxidase has followed the usual routes of investigation such as they were at the start of the 20th century. The electron donors and acceptors were identified and the constituents of the active sites were deduced. It turns out to be a classic, multicentred, redox enzyme. &more...

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Published date: April 2002

Identifiers

Local EPrints ID: 177001
URI: http://eprints.soton.ac.uk/id/eprint/177001
ISSN: 1351-0002
PURE UUID: 7a2a203f-01bf-45b2-874a-f17e3a81c4ca
ORCID for Timothy Millar: ORCID iD orcid.org/0000-0002-4539-2445
ORCID for Janos Kanczler: ORCID iD orcid.org/0000-0001-7249-0414

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Date deposited: 14 Mar 2011 08:27
Last modified: 14 Mar 2024 02:50

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Contributors

Author: Timothy Millar ORCID iD
Author: Janos Kanczler ORCID iD
Author: Tulin Bodamyali
Author: David Blake
Author: Cliff Stevens

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