Antibacterial properties of xanthine oxidase in human milk
Antibacterial properties of xanthine oxidase in human milk
Formula-fed babies contract gastroenteritis more than breast-fed babies, which is of concern to mothers who cannot breastfeed or, as with HIV-infected mothers, are discouraged from breastfeeding. The ability of endogenous breastmilk xanthine oxidase to generate the antimicrobial radical nitric oxide has been measured and its influence on the growth of Escherichia coli and Salmonella enteritides examined. Breastmilk, but not formula feed, generated nitric oxide. Xanthine oxidase activity substantially inhibited the growth of both bacteria. An important natural antibiotic system is missing in formula feeds; the addition of xanthine oxidase may improve formula for use when breastfeeding is not a safe option.
829-830
Stevens, C.R.
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Millar, T.M.
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Clinch, J.G.
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Kanczler, J.M.
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Bodamyali, T
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Blake, D.R.
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September 2000
Stevens, C.R.
70732c45-74f8-4f00-9f5b-f729b7896060
Millar, T.M.
ec88510c-ad88-49f6-8b2d-4277c84c1958
Clinch, J.G.
001c8f83-bb65-4a78-bbd1-c3befca884fd
Kanczler, J.M.
eb8db9ff-a038-475f-9030-48eef2b0559c
Bodamyali, T
a6a94197-db26-4383-8c82-e4f2a20abb24
Blake, D.R.
6e4cc35d-a9b8-459e-bd39-f36501dd735c
Stevens, C.R., Millar, T.M., Clinch, J.G., Kanczler, J.M., Bodamyali, T and Blake, D.R.
(2000)
Antibacterial properties of xanthine oxidase in human milk.
The Lancet, 356 (9232), .
(doi:10.1016/S0140-6736(00)02660-X).
(PMID:11022933)
Abstract
Formula-fed babies contract gastroenteritis more than breast-fed babies, which is of concern to mothers who cannot breastfeed or, as with HIV-infected mothers, are discouraged from breastfeeding. The ability of endogenous breastmilk xanthine oxidase to generate the antimicrobial radical nitric oxide has been measured and its influence on the growth of Escherichia coli and Salmonella enteritides examined. Breastmilk, but not formula feed, generated nitric oxide. Xanthine oxidase activity substantially inhibited the growth of both bacteria. An important natural antibiotic system is missing in formula feeds; the addition of xanthine oxidase may improve formula for use when breastfeeding is not a safe option.
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Published date: September 2000
Organisations:
Infection Inflammation & Immunity
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Local EPrints ID: 177003
URI: http://eprints.soton.ac.uk/id/eprint/177003
ISSN: 0140-6736
PURE UUID: fcc68639-e7aa-4963-b793-48e16567dfd6
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Date deposited: 14 Mar 2011 09:49
Last modified: 14 Mar 2024 02:50
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Author:
C.R. Stevens
Author:
T.M. Millar
Author:
J.G. Clinch
Author:
J.M. Kanczler
Author:
T Bodamyali
Author:
D.R. Blake
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