Prevalence of osteoporosis and fractures among women prescribed osteoporosis medication in five European countries: the POSSIBLE EU ((R)) study
Roux, C., Cooper, C., Diez-Perez, A., Martinez, L., Ortolani, S., Gitlin, M., Moller, G., Shepherd, S. and Freemantle, N. (2011) Prevalence of osteoporosis and fractures among women prescribed osteoporosis medication in five European countries: the POSSIBLE EU ((R)) study. Osteoporosis International, 22, (4), 1227-1236. (doi:10.1007/s00198-010-1321-3). (PMID:20628731).
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Description/Abstract
Summary: European observational 1-year study assessed osteoporosis and fracture patterns in 3,402 postmenopausal women prescribed osteoporosis medication. Almost 40% of patients had a previous fracture, while 25% had neither fracture nor dual energy X-ray absorptiometry (DXA) diagnosis and were prescribed medication, probably due to other risk factors.
Introduction: This analysis assessed osteoporosis and fracture prevalence in postmenopausal women prescribed osteoporosis treatment in the Prospective Observational Study Investigating Bone Loss Experience in Europe(POSSIBLE EU®).
Methods: Women in this observational, multicenter 1-year study were categorized by fracture history and location at baseline. Baseline characteristics were analyzed according to no DXA and DXA diagnosis (osteoporosis or osteopenia). Fractures occurring during the 1-year follow-up period were recorded.
Results: Of the 3,402 women enrolled, 39% had a previous fracture, of whom 30% had ≥2 fractures. One thousand seven hundred and eighty-four (52%) patients had a DXA diagnosis (osteoporosis 68%, osteopenia 31%, and unknown 1%). Among the osteoporosis patients, 37% had a previous fracture (hip 2.9%, vertebral 8.8%, and non-hip, non-vertebral 25%) and 35% had fractures associated with major trauma. Of the 3,402 women, 1,476 (43%) had no DXA diagnosis; of these, 57% had no fracture (25% of all women). Risk factors varied across patients with and without DXA diagnosis. During the 1-year follow-up period, the fracture incidence in patients with or without a previous fracture at baseline was 4.7% and 1.6%, respectively.
Conclusion: Almost 40% of patients prescribed osteoporosis medication had a previous fracture, highlighting a population with advanced disease. In contrast, 25% of patients had neither a previous fracture nor DXA diagnosis and were prescribed treatment, probably due to other risk factors. There is a need for continued improvement of disease management in European women.
| Item Type: | Article |
|---|---|
| ISSNs: | 0937-941X (print) 1433-2965 (electronic) |
| Keywords: | bone, dual energy x-ray absorptiometry, europe, fractures, osteopenia, osteoporosis |
| Subjects: | J Political Science > JZ International relations R Medicine > RC Internal medicine R Medicine > RM Therapeutics. Pharmacology |
| Divisions: | University Structure - Pre August 2011 > School of Medicine |
| Item ID: | 177057 |
| Date Deposited: | 14 Mar 2011 14:41 |
| Last Modified: | 02 Mar 2012 11:36 |
| Contributors: | Roux, C. (Author) Cooper, C. (Author) Diez-Perez, A. (Author) Martinez, L. (Author) Ortolani, S. (Author) Gitlin, M. (Author) Moller, G. (Author) Shepherd, S. (Author) Freemantle, N. (Author) |
| Date: | April 2011 |
| Status: | Published |
| URI: | http://eprints.soton.ac.uk/id/eprint/177057 |
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