GDF5 single-nucleotide polymorphism rs143383 is associated with the lumbar disc degeneration in Northern European women
Williams, F.M.K., Popham, M., Hart, D.J., de Schepper, E., Bierma-Zeinstra, S., Hofman, A., Uitterlinden, A.G., Arden, N.K., Cooper, C., Spector, T.D., Valdes, A. and van Meurs, J. (2011) GDF5 single-nucleotide polymorphism rs143383 is associated with the lumbar disc degeneration in Northern European women. Arthritis & Rheumatism, 63, (3), 708-712. (doi:10.1002/art.30169). (PMID:21360499 ).
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Objective: Lumbar disc degeneration (LDD) is a serious social and medical problem which has been shown to be highly heritable. It has similarities with peripheral joint osteoarthritis (OA) in terms of both epidemiology and pathologic processes. A few known genetic variants have been identified using a candidate gene approach, but many more are thought to exist. GDF5 is a gene whose variants have been shown to play a role in skeletal height as well as predisposing to peripheral joint OA. In vitro, the gene product growth differentiation factor 5 has been shown to promote growth and repair of animal disc. This study was undertaken to investigate whether the GDF5 gene plays a role in LDD.
Methods: We investigated whether the 5? upstream single-nucleotide polymorphism (SNP) variant rs143383 was associated with LDD, using plain radiography and magnetic resonance imaging to identify disc space narrowing and osteophytes, in 5 population cohorts from Northern Europe.
Results: An association between LDD and the SNP rs143383 was identified in women, with the same risk allele as in knee and hip OA (odds ratio 1.72 [95% confidence interval 1.15–2.57], P = 0.008).
Conclusion: Our findings in 5 population cohorts from Northern Europe indicate that a variant in the GDF5 gene is a risk factor for LDD in women. Many more such variants are predicted to exist, but this result highlights the growth and differentiation cellular pathway as a possible route to a better understanding of the process behind lumbar disc degeneration.
|Digital Object Identifier (DOI):||doi:10.1002/art.30169|
|Subjects:||R Medicine > RB Pathology
R Medicine > RC Internal medicine
|Divisions :||University Structure - Pre August 2011 > School of Medicine
|Accepted Date and Publication Date:||
|Date Deposited:||14 Mar 2011 15:44|
|Last Modified:||31 Mar 2016 13:34|
|RDF:||RDF+N-Triples, RDF+N3, RDF+XML, Browse.|
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