Neurophysiological evidence for cognitive and brain functional adaptation in adolescents living at high altitude


Richardson, Cassandra, Hogan, Alexandra M., Bucks, Romola S., Baya, Ana, Virues-Ortega, Javier, Holloway, John W., Rose-Zerilli, Matthew, Palmer, Lyle J., Webster, Rebecca J., Kirkham, Fenella J. and Baldeweg, Torsten (2011) Neurophysiological evidence for cognitive and brain functional adaptation in adolescents living at high altitude. Clinical Neurophysiology, 122, (9), 1726-1734. (doi:10.1016/j.clinph.2011.02.001). (PMID:21377415).

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Description/Abstract

OBJECTIVE: Neurophysiological methods were used to study the effects of high altitude living on brain functions in a subgroup of participants of the Bolivian Children Living at Altitude (BoCLA) project. METHODS: Electroencephalogram (EEG), event-related potentials (ERP) and cerebral blood flow velocity (CBFV) were recorded in two groups of adolescents (aged 13-16years), living either at sea-level or high altitude (∼3700m). RESULTS: Neuropsychological testing revealed no deficits in the high altitude group, despite significantly reduced blood oxygen saturation. In agreement, ERPs elicited by oddball target detection and choice reaction time tasks were not different between groups. In contrast, resting state EEG showed reductions in delta and beta frequency amplitudes in adolescents living at high altitude. The EEG attenuations were correlated with lower CBFV, and the EEG group differences diminished during task performance. CONCLUSIONS: No indication was found for negative sequelae of chronic hypoxia in adolescents born and living at an altitude of ∼3700m, rather evidence for successful neurophysiological adaptation was found under such conditions. SIGNIFICANCE: Dynamic regulation of metabolic demand is one adaptive mechanism that preserves cognitive development at high altitude.

Item Type: Article
ISSNs: 1388-2457 (print)
1872-8952 (electronic)
Keywords: altitude, eeg, erp, adolescence, cognition
Subjects: R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
Q Science > QP Physiology
R Medicine > RJ Pediatrics
Divisions: University Structure - Pre August 2011 > School of Biological Sciences
University Structure - Pre August 2011 > School of Medicine > Clinical Neurosciences
University Structure - Pre August 2011 > School of Medicine > Human Genetics
University Structure - Pre August 2011 > School of Medicine > Infection, Inflammation and Repair
University Structure - Pre August 2011 > School of Psychology
ePrint ID: 177941
Date Deposited: 22 Mar 2011 15:35
Last Modified: 27 Mar 2014 19:26
URI: http://eprints.soton.ac.uk/id/eprint/177941

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