Common variants near CAV1 and CAV2 are associated with primary open-angle glaucoma
Thorleifsson, Gudmar, Walters, G. Bragi, Hewitt, Alex W., Masson, Gisli, Helgason, Agnar, DeWan, Andrew, Sigurdsson, Asgeir, Jonasdottir, Adalbjorg, Gudjonsson, Sigurjon A., Magnusson, Kristinn P, Stefansson, Hreinn, Lam, Dennis S. C., Tam, Pancy O. S., Gudmundsdottir, Gudrun J., Southgate, Laura, Burdon, Kathryn P., Gottfredsdottir, Maria Soffia, Aldred, Micheala A, Mitchell, Paul, St Clair, David, Collier, David A., Tang, Nelson, Sveinsson, Orn, Macgregor, Stuart, Martin, Nicholas G., Cree, Angela J, Gibson, Jane, MacLeod, Alex, Jacob, Aby, Ennis, Sarah, Young, Terri L., Chan, Juliana C. N., Karwatowski, Wojciech S. S., Hammond, Christopher J., Thordarson, Kristjan, Zhang, Mingzhi, Wadelius, Claes, Lotery, Andrew J, Trembath, Richard C., Pang, Chi Pui, Hoh, Josephine, Craig, Jamie E., Kong, Augustine, Mackey, David A., Jonasson, Fridbert, Thorsteinsdottir, Unnur and Stefansson, Kari (2010) Common variants near CAV1 and CAV2 are associated with primary open-angle glaucoma. Nature Genetics, 42, (10), 906-909. (doi:10.1038/ng.661)
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Description/Abstract
We conducted a genome-wide association study for primary open-angle glaucoma (POAG) in 1,263 affected individuals (cases) and 34,877 controls from Iceland. We identified a common sequence variant at 7q31 (rs4236601[A], odds ratio (OR) = 1.36, P = 5.0 × 10−10). We then replicated the association in sample sets of 2,175 POAG cases and 2,064 controls from Sweden, the UK and Australia (combined OR = 1.18, P = 0.0015) and in 299 POAG cases and 580 unaffected controls from Hong Kong and Shantou, China (combined OR =
5.42, P = 0.0021). The risk variant identified here is located close to CAV1 and CAV2, both of which are expressed in the trabecular meshwork and retinal ganglion cells that are involved in the pathogenesis of POAG.
| Item Type: | Article |
|---|---|
| ISSN: | 1061-4036 (print) 1546-1718 (electronic) |
| Related URLs: | http://www.nature.com/ng/journ...ng.661.pdf http://www.ncbi.nlm.nih.gov/pu...d/20835238 |
| Subjects: | Q Science > QH Natural history > QH426 Genetics R Medicine > RE Ophthalmology |
| Divisions: | University Structure - Pre August 2011 > School of Medicine > Clinical Neurosciences University Structure - Pre August 2011 > School of Medicine > Human Genetics |
| ePrint ID: | 177987 |
| URI: | http://eprints.soton.ac.uk/id/eprint/177987 |
| Deposited On: | 22 Mar 2011 14:17 |
| Last Modified: | 02 Mar 2012 13:59 |
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