The effect of combined use of botulinum toxin type A and functional electric stimulation in the treatment of spastic drop foot after stroke: a preliminary investigation
Johnson, Catherine A., Burridge, Jane H., Strike, Paul W., Wood, Duncan E. and Swain, Ian D. (2004) The effect of combined use of botulinum toxin type A and functional electric stimulation in the treatment of spastic drop foot after stroke: a preliminary investigation. Archives of Physical Medicine and Rehabilitation, 85, (6), 902 - 909. (doi:10.1016/j.apmr.2003.08.081)
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Official URL: http://dx.doi.org/10.1016/j.apmr.2003.08.081
Description/Abstract
OBJECTIVE: To investigate the effect of combined botulinum toxin type A (BTX) and functional electric stimulation (FES) treatment on spastic drop foot in stroke.
DESIGN: Nonblinded randomized controlled trial.
SETTING: Hospitals.
PARTICIPANTS: Consecutive sample of 21 ambulant adults within 1 year after stroke with a spastic drop foot, of whom 18 completed the study.
INTERVENTIONS: The treatment group received BTX injections (Dysport) on 1 occasion into the medial and lateral heads of the gastrocnemius (200U each) and tibialis posterior (400U each) muscles and FES, used on a daily basis for 16 weeks to assist walking. Both groups continued with physiotherapy at the same rate.
MAIN OUTCOME MEASURES: Walking speed, Physiological Cost Index, Modified Ashworth Scale, Rivermead Motor Assessment, and Medical Outcomes Study 36-Item Short-Form Health Survey.
RESULTS: Walking speed increased over 12 weeks in both control (P=.020) and treatment groups (nonstimulated, P=.004 stimulated, P=.042). The baseline corrected (analysis of covariance) increase in mean walking speed at 12 weeks, relative to controls, was.04m/s (95% confidence interval [CI],.003-.090) without stimulation, and.09m/s (95% CI,.031-.150) with stimulation.
CONCLUSIONS: Combined treatment effectively improved walking and function. A larger study is needed to quantify the treatment effect and to investigate its impact on quality of life
| Item Type: | Article |
|---|---|
| ISSN: | 0003-9993 (print) |
| Uncontrolled Keywords: | adult, aged, article, assessment, botulinum toxin type a, care, cerebrovascular accident, combined modality therapy, electric stimulation therapy, female, gait disorders neurologic, health, hemiplegia, humans, male, middle aged, muscle spasticity, neuromuscular agents, outcome, outcomes, physiology, physiopathology, quality, quality of life, research support non-u.s.gov't, stroke, therapeutic use, therapy, treatment outcome, walking |
| Related URLs: | http://www.ncbi.nlm.nih.gov/en...s=15179643 http://dx.doi.org/10.1016/j.ap...003.08.081 |
| Subjects: | T Technology > TK Electrical engineering. Electronics Nuclear engineering R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry R Medicine > RM Therapeutics. Pharmacology |
| Divisions: | University Structure - Pre August 2011 > Superseded (SOHPRS) |
| ePrint ID: | 17928 |
| URI: | http://eprints.soton.ac.uk/id/eprint/17928 |
| Deposited On: | 21 Nov 2005 |
| Last Modified: | 01 Apr 2012 01:34 |
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