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Effects of multi-sensory stimulation in people with Huntington's Disease: a randomised controlled pilot study

Effects of multi-sensory stimulation in people with Huntington's Disease: a randomised controlled pilot study
Effects of multi-sensory stimulation in people with Huntington's Disease: a randomised controlled pilot study
OBJECTIVE: To investigate whether behavioural, motor and physiological responses of individuals with Huntington's disease (HD) to a controlled multisensory environment (MSE) are effective as a therapeutic (sustained effects) or leisure (immediate effects) activity. DESIGN: Pilot study--a randomized, controlled, two-group design. SETTING: Specialist residential unit for people with mid-late stage HD. SUBJECTS: Twelve patients with HD (one subject from each group dropped out during the study after week 8 due to medical complications). INTERVENTIONS: Patients attended eight, 30-minute sessions over a four-week period, of multisensory stimulation (MSE, treatment group) or relaxation activities (control group). MAIN OUTCOME MEASURES: Between-group comparisons for changes between assessment sessions for two behavioural assessments: Rehabilitation Evaluation--Hall and Baker (REHAB), Behaviour and Mood Disturbance Scale (BMD) a motor assessment: the dyskinesia section of the St Hans Rating Scale (SHRS); physiological measures: blood pressure, heart rate and respiratory rate. Secondary measures during intervention sessions included behavioural assessment using the Interact. RESULTS: There were no significant differences found between the groups for any main outcome measures made between sessions. The MSE group showed some positive effects within-sessions, with the Interact showing significant between-group differences in immediate effects on mood (p = 0.028). There was also a significantly different change over time for within-session changes in stimulation levels (p = 0.0002) and mood (p = 0.0001) between the groups. No physiological effects were observed in relation to sessions in either group. Two MSE subjects underwent changes in medication during the study period. CONCLUSIONS: There was no therapeutic effect of MSEs over the four-week study period. MSEs appear to be more effective thanconventional relaxation techniques as a leisure activity
disease
0269-2155
30 -41
Leng, T.
616d6426-37c2-4731-8c67-2c5df16fb2e6
Woodward, M.
c9d7039c-6bef-4e99-b420-fbee1f675a14
Stokes, M. J.
3c15362e-6093-4652-a6f9-b472f78d5d85
Swan, A. V.
2350f62a-fcb8-4d3b-a6e3-148d428f68e1
Wareing, L. A.
ccba53c5-a3dd-4a00-b2a9-9cf9f692958a
Barker, R.
a4e2233d-5d28-43cd-a9dc-047be7bd145b
Leng, T.
616d6426-37c2-4731-8c67-2c5df16fb2e6
Woodward, M.
c9d7039c-6bef-4e99-b420-fbee1f675a14
Stokes, M. J.
3c15362e-6093-4652-a6f9-b472f78d5d85
Swan, A. V.
2350f62a-fcb8-4d3b-a6e3-148d428f68e1
Wareing, L. A.
ccba53c5-a3dd-4a00-b2a9-9cf9f692958a
Barker, R.
a4e2233d-5d28-43cd-a9dc-047be7bd145b

Leng, T., Woodward, M., Stokes, M. J., Swan, A. V., Wareing, L. A. and Barker, R. (2003) Effects of multi-sensory stimulation in people with Huntington's Disease: a randomised controlled pilot study. Clinical Rehabilitation, 17 (1), 30 -41. (doi:10.1191/0269215503cr582oa).

Record type: Article

Abstract

OBJECTIVE: To investigate whether behavioural, motor and physiological responses of individuals with Huntington's disease (HD) to a controlled multisensory environment (MSE) are effective as a therapeutic (sustained effects) or leisure (immediate effects) activity. DESIGN: Pilot study--a randomized, controlled, two-group design. SETTING: Specialist residential unit for people with mid-late stage HD. SUBJECTS: Twelve patients with HD (one subject from each group dropped out during the study after week 8 due to medical complications). INTERVENTIONS: Patients attended eight, 30-minute sessions over a four-week period, of multisensory stimulation (MSE, treatment group) or relaxation activities (control group). MAIN OUTCOME MEASURES: Between-group comparisons for changes between assessment sessions for two behavioural assessments: Rehabilitation Evaluation--Hall and Baker (REHAB), Behaviour and Mood Disturbance Scale (BMD) a motor assessment: the dyskinesia section of the St Hans Rating Scale (SHRS); physiological measures: blood pressure, heart rate and respiratory rate. Secondary measures during intervention sessions included behavioural assessment using the Interact. RESULTS: There were no significant differences found between the groups for any main outcome measures made between sessions. The MSE group showed some positive effects within-sessions, with the Interact showing significant between-group differences in immediate effects on mood (p = 0.028). There was also a significantly different change over time for within-session changes in stimulation levels (p = 0.0002) and mood (p = 0.0001) between the groups. No physiological effects were observed in relation to sessions in either group. Two MSE subjects underwent changes in medication during the study period. CONCLUSIONS: There was no therapeutic effect of MSEs over the four-week study period. MSEs appear to be more effective thanconventional relaxation techniques as a leisure activity

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Published date: 2003
Keywords: disease

Identifiers

Local EPrints ID: 17949
URI: http://eprints.soton.ac.uk/id/eprint/17949
ISSN: 0269-2155
PURE UUID: c5c573aa-28a0-4e26-8607-22711e8e98af

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Date deposited: 27 Oct 2005
Last modified: 15 Mar 2024 06:02

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Contributors

Author: T. Leng
Author: M. Woodward
Author: M. J. Stokes
Author: A. V. Swan
Author: L. A. Wareing
Author: R. Barker

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