Nanomolar detection with high sensitivity microfluidic absorption cells manufactured in tinted PMMA for chemical analysis


Floquet, Cedric F.A., Sieben, Vincent J., Milani, Ambra, Joly, E, Ogilvie, Iain R.G., Morgan, Hywel and Mowlem, Matthew C. (2011) Nanomolar detection with high sensitivity microfluidic absorption cells manufactured in tinted PMMA for chemical analysis. Talanta, 84, (1), 235-239. (doi:10.1016/j.talanta.2010.12.026).

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Description/Abstract

We describe a novel, cost effective and simple technique for the manufacture of high sensitivity absorption cells for microfluidic analytical systems. The cells are made from tinted polymethyl methacrylate (PMMA) in which microfluidic channels are fabricated. Two windows (typically 250 μm thick, resulting in little optical power loss) are formed at either end of the channel through which light is coupled. Unwanted stray light from the emitter passes through a greater thickness of the tinted substrate (typically the length of the cell) and is preferentially absorbed. In effect, this creates a pin-hole configuration over the length of the absorption cell, providing improved performances (sensitivity, S/N ratios, baseline noise and limit of detection) when used as an absorption cell compared to clear substrates. The method is used to achieve a LOD of 20 nM with a colourimetric iron assay and a LOD of 0.22 milli-absorption units with a pH assay.

Item Type: Article
ISSNs: 0039-9140
Keywords: Microfluidic; PMMA; Colourimetric assays; Absorption; Microsensors
Subjects: T Technology > TP Chemical technology
Divisions: University Structure - Pre August 2011 > National Oceanography Centre (NERC)
University Structure - Pre August 2011 > School of Electronics and Computer Science
University Structure - Pre August 2011 > School of Electronics and Computer Science > Nano-Scale Integration Group
National Oceanography Centre (NERC) > Ocean Technology and Engineering
ePrint ID: 179503
Date Deposited: 01 Apr 2011 13:01
Last Modified: 14 Apr 2014 10:56
Research Funder: EPSRC
Projects:
Ruggedised MicroSystem Technology for marine measurement
Funded by: EPSRC (EP/E016774/1)
Led by: Hywel Morgan
1 June 2007 to 30 November 2011
URI: http://eprints.soton.ac.uk/id/eprint/179503

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