Environmental impoverishment and aging alter object recognition, spatial learning, and dentate gyrus astrocytes

Diniz, Daniel G., Foro, César A. R., Rego, Carla M. D., Gloria, David A., De Oliveira, Fabio R. R., Paes, Juliana M. P., De Sousa, Aline A., Tokuhashi, Tatyana P., Trindade, Lucas S., Turiel, Maíra C. P., Vasconcelos, Erick G. R., Torres, João B., Cunnigham, Colm, Perry, Victor Hugh, Da Costa Vasconcelos, Pedro F. and Diniz, Cristovam W. P. (2010) Environmental impoverishment and aging alter object recognition, spatial learning, and dentate gyrus astrocytes. European Journal of Neuroscience, 32, (3), 509-519. (doi:10.1111/j.1460-9568.2010.07296.x). (PMID:20704596 ).


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Environmental and age-related effects on learning and memory were analysed and compared with changes observed in astrocyte laminar distribution in the dentate gyrus. Aged (20 months) and young (6 months) adult female albino Swiss mice were housed from weaning either in impoverished conditions or in enriched conditions, and tested for episodic-like and water maze spatial memories. After these behavioral tests, brain hippocampal sections were immunolabeled for glial fibrillary acid protein to identify astrocytes. The effects of environmental enrichment on episodic-like memory were not dependent on age, and may protect water maze spatial learning and memory from declines induced by aging or impoverished environment. In the dentate gyrus, the number of astrocytes increased with both aging and enriched environment in the molecular layer, increased only with aging in the polymorphic layer, and was unchanged in the granular layer. We suggest that long-term experience-induced glial plasticity by enriched environment may represent at least part of the circuitry groundwork for improvements in behavioral performance in the aged mice brain

Item Type: Article
Digital Object Identifier (DOI): doi:10.1111/j.1460-9568.2010.07296.x
ISSNs: 0953-816X (print)
1460-9568 (electronic)
Subjects: R Medicine > R Medicine (General)
Divisions : University Structure - Pre August 2011 > School of Biological Sciences
ePrint ID: 180195
Accepted Date and Publication Date:
August 2010Published
Date Deposited: 06 Apr 2011 08:20
Last Modified: 31 Mar 2016 13:35
URI: http://eprints.soton.ac.uk/id/eprint/180195

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