The University of Southampton
University of Southampton Institutional Repository

Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease

Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease
Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease
We performed a meta-analysis of 14 genome-wide association studies of coronary artery disease (CAD) comprising 22,233 individuals with CAD (cases) and 64,762 controls of European descent followed by genotyping of top association signals in 56,682 additional individuals. This analysis identified 13 loci newly associated with CAD at P < 5 × 10?? and confirmed the association of 10 of 12 previously reported CAD loci. The 13 new loci showed risk allele frequencies ranging from 0.13 to 0.91 and were associated with a 6% to 17% increase in the risk of CAD per allele. Notably, only three of the new loci showed significant association with traditional CAD risk factors and the majority lie in gene regions not previously implicated in the pathogenesis of CAD. Finally, five of the new CAD risk loci appear to have pleiotropic effects, showing strong association with various other human diseases or traits
1061-4036
333-338
Schunkert, Heribert
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König, Inke R.
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Kathiresan, Sekar
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Reilly, Muredach P.
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Assimes, Themistocles L.
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Holm, Hilma
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Preuss, Michael
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Stewart, Alexandre F.R.
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Barbalic, Maja
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Ardissino, Diego
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Ball, Stephen G.
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Balmforth, Anthony J.
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Jones, Gregory T
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Jukema, J Wouter
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Lettre, Guillaume
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Hofman, Albert
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Schunkert, Heribert, König, Inke R., Kathiresan, Sekar, Reilly, Muredach P., Assimes, Themistocles L., Holm, Hilma, Preuss, Michael, Stewart, Alexandre F.R., Barbalic, Maja, Gieger, Christian, Absher, Devin, Aherrahrou, Zouhair, Allayee, Hooman, Altshuler, David, Anand, Sonia S., Andersen, Karl, Anderson, Jeffrey L., Ardissino, Diego, Ball, Stephen G., Balmforth, Anthony J., Barnes, Timothy A., Becker, Diane M., Becker, Lewis C., Berger, Klaus, Bis, Joshua C., Boekholdt, S. Matthijs, Boerwinkle, Eric, Braund, Peter S., Brown, Morris J., Burnett, Mary Susan, Buysschaert, Ian, Carlquist, John F., Chen, Li, Cichon, Sven, Codd, Veryan, Davies, Robert W., Dedoussis, George, Dehghan, Abbas, Demissie, Serkalem, Devaney, Joseph M., Diemert, Patrick, Do, Ron, Doering, Angela, Eifert, Sandra, Mokhtari, Nour Eddine El, Ellis, Stephen G., Elosua, Roberto, Engert, James C., Epstein, Stephen E., de Faire, Ulf, Fischer, Marcus, Folsom, Aaron R., Freyer, Jennifer, Gigante, Bruna, Girelli, Domenico, Gretarsdottir, Solveig, Gudnason, Vilmundur, Gulcher, Jeffrey R., Halperin, Eran, Hammond, Naomi, Hazen, Stanley L, Hofman, Albert, Horne, Benjamin D., Illig, Thomas, Iribarren, Carlos, Jones, Gregory T, Jukema, J Wouter, Kaiser, Michael A., Kaplan, Lee M., Kastelein, John J.P., Khaw, Kay-Tee, Knowles, Joshua W., Kolovou, Genovefa, Kong, Augustine, Laaksonen, Reijo, Lambrechts, Diether, Leander, Karin, Lettre, Guillaume, Li, Mingyao, Lieb, Wolfgang, Loley, Christina, Lotery, Andrew J, Mannucci, Pier M., Maouche, Seraya, Martinelli, Nicola, McKeown, Pascal P., Meisinger, Christa, Meitinger, Thomas, Melander, Olle, Merlini, Pier Angelica, Mooser, Vincent, Morgan, Thomas, Mühleisen, Thomas W., Muhlestein, Joseph B., Münzel, Thomas, Musunuru, Kiran, Nahrstaedt, Janja, Nelson, Christopher P., Nöthen, Markus M, Olivieri, Oliviero, Patel, Riyaz S., Patterson, Chris C., Peters, Annette, Peyvandi, Flora, Qu, Liming, Quyyumi, Arshed A., Rader, Daniel J., Rallidis, Loukianos S., Rice, Catherine, Rosendaal, Frits R., Rubin, Diana, Salomaa, Veikko, Sampietro, M Lourdes, Sandhu, Manj S., Schadt, Eric, Schäfer, Arne, Schillert, Arne, Schreiber, Stefan, Schrezenmeir, Jürgen, Schwartz, Stephen M., Siscovick, David S., Sivananthan, Mohan, Sivapalaratnam, Suthesh, Smith, Albert, Smith, Tamara B., Snoep, Jaapjan D., Soranzo, Nicole, Spertus, John A., Stark, Klaus, Stirrups, Kathy, Stoll, Monika, Tang, W.H. Wilson, Tennstedt, Stephanie, Thorgeirsson, Gudmundur, Thorleifsson, Gudmar, Tomaszewski, Maciej, Uitterlinden, Andre G., van Rij, Andre M., Voight, Benjamin F., Wareham, Nick J., Wells, George A., Wichmann, H-Erich, Wild, Philipp S., Willenborg, Christina, Witteman, Jaqueline C.M., Wright, Benjamin J., Ye, Shu, Zeller, Tanja, Ziegler, Andreas, Cambien, Francois, Goodall, Alison H., Cupples, L Adrienne, Quertermous, Thomas, März, Winfried, Hengstenberg, Christian, Blankenberg, Stefan, Ouwehand, Willem H., Hall, Alistair S., Deloukas, Panos, Thompson, John R., Stefansson, Kari, Roberts, Robert, Thorsteinsdottir, Unnur, O'Donnell, Christopher J., McPherson, Ruth, Erdmann, Jeanette and Samani, Nilesh J. (2011) Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease. Nature Genetics, 43 (4), 333-338. (doi:10.1038/ng.784). (PMID:21378990)

Record type: Article

Abstract

We performed a meta-analysis of 14 genome-wide association studies of coronary artery disease (CAD) comprising 22,233 individuals with CAD (cases) and 64,762 controls of European descent followed by genotyping of top association signals in 56,682 additional individuals. This analysis identified 13 loci newly associated with CAD at P < 5 × 10?? and confirmed the association of 10 of 12 previously reported CAD loci. The 13 new loci showed risk allele frequencies ranging from 0.13 to 0.91 and were associated with a 6% to 17% increase in the risk of CAD per allele. Notably, only three of the new loci showed significant association with traditional CAD risk factors and the majority lie in gene regions not previously implicated in the pathogenesis of CAD. Finally, five of the new CAD risk loci appear to have pleiotropic effects, showing strong association with various other human diseases or traits

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Published date: March 2011

Identifiers

Local EPrints ID: 180685
URI: http://eprints.soton.ac.uk/id/eprint/180685
ISSN: 1061-4036
PURE UUID: 61d6eb52-afd0-4cc9-8f99-81420e4c3b7f
ORCID for Andrew J Lotery: ORCID iD orcid.org/0000-0001-5541-4305

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Date deposited: 11 Apr 2011 10:26
Last modified: 15 Mar 2024 03:15

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Contributors

Author: Heribert Schunkert
Author: Inke R. König
Author: Sekar Kathiresan
Author: Muredach P. Reilly
Author: Themistocles L. Assimes
Author: Hilma Holm
Author: Michael Preuss
Author: Alexandre F.R. Stewart
Author: Maja Barbalic
Author: Christian Gieger
Author: Devin Absher
Author: Zouhair Aherrahrou
Author: Hooman Allayee
Author: David Altshuler
Author: Sonia S. Anand
Author: Karl Andersen
Author: Jeffrey L. Anderson
Author: Diego Ardissino
Author: Stephen G. Ball
Author: Anthony J. Balmforth
Author: Timothy A. Barnes
Author: Diane M. Becker
Author: Lewis C. Becker
Author: Klaus Berger
Author: Joshua C. Bis
Author: S. Matthijs Boekholdt
Author: Eric Boerwinkle
Author: Peter S. Braund
Author: Morris J. Brown
Author: Mary Susan Burnett
Author: Ian Buysschaert
Author: John F. Carlquist
Author: Li Chen
Author: Sven Cichon
Author: Veryan Codd
Author: Robert W. Davies
Author: George Dedoussis
Author: Abbas Dehghan
Author: Serkalem Demissie
Author: Joseph M. Devaney
Author: Patrick Diemert
Author: Ron Do
Author: Angela Doering
Author: Sandra Eifert
Author: Nour Eddine El Mokhtari
Author: Stephen G. Ellis
Author: Roberto Elosua
Author: James C. Engert
Author: Stephen E. Epstein
Author: Ulf de Faire
Author: Marcus Fischer
Author: Aaron R. Folsom
Author: Jennifer Freyer
Author: Bruna Gigante
Author: Domenico Girelli
Author: Solveig Gretarsdottir
Author: Vilmundur Gudnason
Author: Jeffrey R. Gulcher
Author: Eran Halperin
Author: Naomi Hammond
Author: Stanley L Hazen
Author: Albert Hofman
Author: Benjamin D. Horne
Author: Thomas Illig
Author: Carlos Iribarren
Author: Gregory T Jones
Author: J Wouter Jukema
Author: Michael A. Kaiser
Author: Lee M. Kaplan
Author: John J.P. Kastelein
Author: Kay-Tee Khaw
Author: Joshua W. Knowles
Author: Genovefa Kolovou
Author: Augustine Kong
Author: Reijo Laaksonen
Author: Diether Lambrechts
Author: Karin Leander
Author: Guillaume Lettre
Author: Mingyao Li
Author: Wolfgang Lieb
Author: Christina Loley
Author: Andrew J Lotery ORCID iD
Author: Pier M. Mannucci
Author: Seraya Maouche
Author: Nicola Martinelli
Author: Pascal P. McKeown
Author: Christa Meisinger
Author: Thomas Meitinger
Author: Olle Melander
Author: Pier Angelica Merlini
Author: Vincent Mooser
Author: Thomas Morgan
Author: Thomas W. Mühleisen
Author: Joseph B. Muhlestein
Author: Thomas Münzel
Author: Kiran Musunuru
Author: Janja Nahrstaedt
Author: Christopher P. Nelson
Author: Markus M Nöthen
Author: Oliviero Olivieri
Author: Riyaz S. Patel
Author: Chris C. Patterson
Author: Annette Peters
Author: Flora Peyvandi
Author: Liming Qu
Author: Arshed A. Quyyumi
Author: Daniel J. Rader
Author: Loukianos S. Rallidis
Author: Catherine Rice
Author: Frits R. Rosendaal
Author: Diana Rubin
Author: Veikko Salomaa
Author: M Lourdes Sampietro
Author: Manj S. Sandhu
Author: Eric Schadt
Author: Arne Schäfer
Author: Arne Schillert
Author: Stefan Schreiber
Author: Jürgen Schrezenmeir
Author: Stephen M. Schwartz
Author: David S. Siscovick
Author: Mohan Sivananthan
Author: Suthesh Sivapalaratnam
Author: Albert Smith
Author: Tamara B. Smith
Author: Jaapjan D. Snoep
Author: Nicole Soranzo
Author: John A. Spertus
Author: Klaus Stark
Author: Kathy Stirrups
Author: Monika Stoll
Author: W.H. Wilson Tang
Author: Stephanie Tennstedt
Author: Gudmundur Thorgeirsson
Author: Gudmar Thorleifsson
Author: Maciej Tomaszewski
Author: Andre G. Uitterlinden
Author: Andre M. van Rij
Author: Benjamin F. Voight
Author: Nick J. Wareham
Author: George A. Wells
Author: H-Erich Wichmann
Author: Philipp S. Wild
Author: Christina Willenborg
Author: Jaqueline C.M. Witteman
Author: Benjamin J. Wright
Author: Shu Ye
Author: Tanja Zeller
Author: Andreas Ziegler
Author: Francois Cambien
Author: Alison H. Goodall
Author: L Adrienne Cupples
Author: Thomas Quertermous
Author: Winfried März
Author: Christian Hengstenberg
Author: Stefan Blankenberg
Author: Willem H. Ouwehand
Author: Alistair S. Hall
Author: Panos Deloukas
Author: John R. Thompson
Author: Kari Stefansson
Author: Robert Roberts
Author: Unnur Thorsteinsdottir
Author: Christopher J. O'Donnell
Author: Ruth McPherson
Author: Jeanette Erdmann
Author: Nilesh J. Samani

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