Tetrazine–trans-cyclooctene ligation for the rapid construction of 18F labeled probes


Li, Zibo, Cai, Hancheng, Hassink, Matthew, Blackman, Melissa L., Brown, Richard C.D., Conti, Peter S. and Fox, Joseph M. (2010) Tetrazine–trans-cyclooctene ligation for the rapid construction of 18F labeled probes. Chemical Communications, 46, (42), 8043-8045. (doi:10.1039/C0cc03078c). (PMID:20862423).

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Description/Abstract

A radiolabeling method for bioconjugation based on the
Diels–Alder reaction between 3,6-diaryl-s-tetrazines and an
18F-labeled trans-cyclooctene is described. The reaction proceeds with exceptionally fast rates, making it an effective conjugation method within seconds at low micromolar concentrations.

Item Type: Article
Digital Object Identifier (DOI): doi:10.1039/C0cc03078c
ISSNs: 1359-7345 (print)
1364-548X (electronic)
Subjects: H Social Sciences > HE Transportation and Communications
Q Science > QD Chemistry
T Technology > TA Engineering (General). Civil engineering (General)
Divisions : University Structure - Pre August 2011 > School of Chemistry
ePrint ID: 180733
Accepted Date and Publication Date:
Status
2010Published
Date Deposited: 12 Apr 2011 08:27
Last Modified: 31 Mar 2016 13:35
URI: http://eprints.soton.ac.uk/id/eprint/180733

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