Tetrazine–trans-cyclooctene ligation for the rapid construction of 18F labeled probes
Li, Zibo, Cai, Hancheng, Hassink, Matthew, Blackman, Melissa L., Brown, Richard C.D., Conti, Peter S. and Fox, Joseph M. (2010) Tetrazine–trans-cyclooctene ligation for the rapid construction of 18F labeled probes. Chemical Communications, 46, (42), 8043-8045. (doi:10.1039/C0cc03078c). (PMID:20862423).
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Description/Abstract
A radiolabeling method for bioconjugation based on the
Diels–Alder reaction between 3,6-diaryl-s-tetrazines and an
18F-labeled trans-cyclooctene is described. The reaction proceeds with exceptionally fast rates, making it an effective conjugation method within seconds at low micromolar concentrations.
| Item Type: | Article |
|---|---|
| ISSNs: | 1359-7345 (print) 1364-548X (electronic) |
| Subjects: | H Social Sciences > HE Transportation and Communications Q Science > QD Chemistry T Technology > TA Engineering (General). Civil engineering (General) |
| Divisions: | University Structure - Pre August 2011 > School of Chemistry |
| Item ID: | 180733 |
| Date Deposited: | 12 Apr 2011 08:27 |
| Last Modified: | 02 Mar 2012 13:16 |
| Contributors: | Li, Zibo (Author) Cai, Hancheng (Author) Hassink, Matthew (Author) Blackman, Melissa L. (Author) Brown, Richard C.D. (Author) Conti, Peter S. (Author) Fox, Joseph M. (Author) |
| Date: | 2010 |
| Status: | Published |
| URI: | http://eprints.soton.ac.uk/id/eprint/180733 |
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