Integrated systems for rapid point of care (PoC) blood cell analysis


van Berkel, Cees, Gwyer, James D., Deane, Steve, Green, Nicolas, Holloway, Judith, Hollis, Veronica and Morgan, Hywel (2011) Integrated systems for rapid point of care (PoC) blood cell analysis. Lab on a Chip - Miniturisation for Chemistry and Biology, 11, (7), 1249-1255. (doi:10.1039/C0LC00587H). (PMID:21331413).

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Description/Abstract

Counting the different subpopulations of cells in a fingerprick of human blood is important for a number of clinical point-of-care (PoC) applications. It is a challenge to demonstrate the integration of sample preparation and detection techniques in a single platform. In this paper we demonstrate a generic microfluidic platform that combines sample processing and characterisation and enumeration in a single, integrated system. Results of microfluidic 3-part differential leukocyte (granulocyte, lymphocyte and monocyte) counts, together with erythrocyte and thrombocyte (platelet) counts, in human blood are shown and corroborated with results from hospital clinical laboratory analysis.

Item Type: Article
ISSNs: 1473-0197 (print)
1473-0189 (electronic)
Related URLs:
Subjects: Q Science > QH Natural history > QH301 Biology
R Medicine > R Medicine (General)
Divisions: University Structure - Pre August 2011 > School of Electronics and Computer Science
University Structure - Pre August 2011 > School of Engineering Sciences
University Structure - Pre August 2011 > School of Medicine > Infection, Inflammation and Repair
ePrint ID: 181025
Date Deposited: 13 Apr 2011 10:20
Last Modified: 14 Apr 2014 10:57
Projects:
Point of Care Blood Cell Analysis
Funded by: EPSRC (TS/G001405/1)
Led by: Hywel Morgan
1 January 2009 to 31 December 2012
URI: http://eprints.soton.ac.uk/id/eprint/181025

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