In-vivo quantification of bacterial keratitis with optical coherence tomography
In-vivo quantification of bacterial keratitis with optical coherence tomography
PURPOSE: To quantify the human corneal inflammatory response in treated bacterial keratitis with long-wavelength anterior segment optical coherence tomography (AS-OCT).
METHODS: Patients with clinically suspected bacterial keratitis were recruited from the corneal service at Southampton Eye Unit, UK. Patients underwent AS-OCT and slit-lamp examination on presentation (day 0) and days 3, 7, and 14 of treatment. Corneal thickness (CT) in the infiltrated area, infiltrate thickness (IT), and infiltrate width (IW) were measured on high-resolution AS-OCT scans. Mean values for each day and rates of change for each interval were calculated and compared (one-way ANOVA, paired t-test).
RESULTS: Twenty-six eyes of 26 patients were recruited. Mean CT and IT on presentation were 905 ?m and 388 ?m, respectively. On days 3, 7, and 14, CT and IT decreased to 753 ?m and 320 ?m (P < 0.01), 678 ?m and 296 ?m (P < 0.01), and 584 ?m and 207 ?m (P < 0.01), respectively. Mean IW, 1498 ?m on presentation, did not change during treatment (P > 0.30). Mean daily rate of CT reduction was faster in the early (days 0-3) compared to late (days 7-14) phase (4.49% vs. 1.33%, P = 0.006). Mean daily rate of IT reduction was no different in early, middle, and late phases (5.41% vs. 1.19% vs. 3.38%, P > 0.01). In the late phase, IT decreased faster than CT (3.38% vs. 1.33%, P = 0.003).
CONCLUSIONS: CT and IT decreased significantly by day 3 in resolving bacterial keratitis. The rapid early phase reduction in IT and CT was followed by rapid late phase IT reduction. This study demonstrates that serial AS-OCT examination can be used to monitor in vivo the clinical course of inflammatory disease.
1093-1097
Konstantopoulos, Aris
7758cee7-c139-4ce0-96d3-ac4d3f4c1563
Fievez, Marina
a02e1231-bf95-43b0-a14a-0168533b41db
Anderson, David
ace373df-c58c-4cd4-941f-1a596a62b5a8
Hossain, Parwez
563de5fc-84ad-4539-9228-bde0237eaf51
October 2010
Konstantopoulos, Aris
7758cee7-c139-4ce0-96d3-ac4d3f4c1563
Fievez, Marina
a02e1231-bf95-43b0-a14a-0168533b41db
Anderson, David
ace373df-c58c-4cd4-941f-1a596a62b5a8
Hossain, Parwez
563de5fc-84ad-4539-9228-bde0237eaf51
Konstantopoulos, Aris, Fievez, Marina, Anderson, David and Hossain, Parwez
(2010)
In-vivo quantification of bacterial keratitis with optical coherence tomography.
Investigative Ophthalmology & Visual Science, 52 (2), .
(doi:10.1167/iovs.10-6067).
(PMID:20926816)
Abstract
PURPOSE: To quantify the human corneal inflammatory response in treated bacterial keratitis with long-wavelength anterior segment optical coherence tomography (AS-OCT).
METHODS: Patients with clinically suspected bacterial keratitis were recruited from the corneal service at Southampton Eye Unit, UK. Patients underwent AS-OCT and slit-lamp examination on presentation (day 0) and days 3, 7, and 14 of treatment. Corneal thickness (CT) in the infiltrated area, infiltrate thickness (IT), and infiltrate width (IW) were measured on high-resolution AS-OCT scans. Mean values for each day and rates of change for each interval were calculated and compared (one-way ANOVA, paired t-test).
RESULTS: Twenty-six eyes of 26 patients were recruited. Mean CT and IT on presentation were 905 ?m and 388 ?m, respectively. On days 3, 7, and 14, CT and IT decreased to 753 ?m and 320 ?m (P < 0.01), 678 ?m and 296 ?m (P < 0.01), and 584 ?m and 207 ?m (P < 0.01), respectively. Mean IW, 1498 ?m on presentation, did not change during treatment (P > 0.30). Mean daily rate of CT reduction was faster in the early (days 0-3) compared to late (days 7-14) phase (4.49% vs. 1.33%, P = 0.006). Mean daily rate of IT reduction was no different in early, middle, and late phases (5.41% vs. 1.19% vs. 3.38%, P > 0.01). In the late phase, IT decreased faster than CT (3.38% vs. 1.33%, P = 0.003).
CONCLUSIONS: CT and IT decreased significantly by day 3 in resolving bacterial keratitis. The rapid early phase reduction in IT and CT was followed by rapid late phase IT reduction. This study demonstrates that serial AS-OCT examination can be used to monitor in vivo the clinical course of inflammatory disease.
Text
iovs.10-6067.full.pdf
- Accepted Manuscript
Restricted to Repository staff only
Request a copy
More information
Published date: October 2010
Organisations:
Infection Inflammation & Immunity
Identifiers
Local EPrints ID: 181577
URI: http://eprints.soton.ac.uk/id/eprint/181577
ISSN: 0146-0404
PURE UUID: 0e8d2cdb-dd8a-420b-a769-34b45f86a4ab
Catalogue record
Date deposited: 19 Apr 2011 10:31
Last modified: 15 Mar 2024 03:24
Export record
Altmetrics
Contributors
Author:
Aris Konstantopoulos
Author:
Marina Fievez
Author:
David Anderson
Download statistics
Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.
View more statistics