Filaggrin null mutations associate with increased frequencies of allergen-specific CD4+ T-helper 2 cells in patients with atopic eczema


McPherson, T., Sherman, V. J. , Aslam, A., Crack, L., Chan, H., Lloyd-Lavery, A., Jones, L.E., Ardern-Jones, M and Ogg, G. (2010) Filaggrin null mutations associate with increased frequencies of allergen-specific CD4+ T-helper 2 cells in patients with atopic eczema. British Journal of Dermatology, 163, (3), 544-549. (doi:10.1111/j.1365-2133.2010.09866.x). (PMID:20500796).

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Description/Abstract

These data would support a model where barrier dysfunction possibly promotes greater allergen penetration and delivery to drive allergen-specific CD4+ T cells. This could further contribute to respiratory and cutaneous inflammatory disease.

Item Type: Article
ISSNs: 0007-0963 (print)
1365-2133 (electronic)
Related URLs:
Subjects: R Medicine > R Medicine (General)
R Medicine > RL Dermatology
Divisions: University Structure - Pre August 2011 > School of Medicine > Infection, Inflammation and Repair
ePrint ID: 181625
Date Deposited: 15 Apr 2011 11:12
Last Modified: 27 Mar 2014 19:34
URI: http://eprints.soton.ac.uk/id/eprint/181625

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