Filaggrin null mutations associate with increased frequencies of allergen-specific CD4+ T-helper 2 cells in patients with atopic eczema
McPherson, T., Sherman, V. J. , Aslam, A., Crack, L., Chan, H., Lloyd-Lavery, A., Jones, L.E., Ardern-Jones, M and Ogg, G. (2010) Filaggrin null mutations associate with increased frequencies of allergen-specific CD4+ T-helper 2 cells in patients with atopic eczema. British Journal of Dermatology, 163, (3), 544-549. (doi:10.1111/j.1365-2133.2010.09866.x). (PMID:20500796).
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These data would support a model where barrier dysfunction possibly promotes greater allergen penetration and delivery to drive allergen-specific CD4+ T cells. This could further contribute to respiratory and cutaneous inflammatory disease.
|Subjects:||R Medicine > R Medicine (General)
R Medicine > RL Dermatology
|Divisions:||University Structure - Pre August 2011 > School of Medicine > Infection, Inflammation and Repair
|Date Deposited:||15 Apr 2011 11:12|
|Last Modified:||01 Jun 2011 17:52|
|Contributors:||McPherson, T. (Author)
Sherman, V. J. (Author)
Aslam, A. (Author)
Crack, L. (Author)
Chan, H. (Author)
Lloyd-Lavery, A. (Author)
Jones, L.E. (Author)
Ardern-Jones, M (Author)
Ogg, G. (Author)
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