Filaggrin null mutations associate with increased frequencies of allergen-specific CD4+ T-helper 2 cells in patients with atopic eczema
McPherson, T., Sherman, V. J. , Aslam, A., Crack, L., Chan, H., Lloyd-Lavery, A., Jones, L.E., Ardern-Jones, M and Ogg, G. (2010) Filaggrin null mutations associate with increased frequencies of allergen-specific CD4+ T-helper 2 cells in patients with atopic eczema. British Journal of Dermatology, 163, (3), 544-549. (doi:10.1111/j.1365-2133.2010.09866.x). (PMID:20500796).
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Description/Abstract
These data would support a model where barrier dysfunction possibly promotes greater allergen penetration and delivery to drive allergen-specific CD4+ T cells. This could further contribute to respiratory and cutaneous inflammatory disease.
| Item Type: | Article |
|---|---|
| ISSNs: | 0007-0963 (print) 1365-2133 (electronic) |
| Related URLs: | |
| Subjects: | R Medicine > R Medicine (General) R Medicine > RL Dermatology |
| Divisions: | University Structure - Pre August 2011 > School of Medicine > Infection, Inflammation and Repair |
| Item ID: | 181625 |
| Date Deposited: | 15 Apr 2011 11:12 |
| Last Modified: | 01 Jun 2011 17:52 |
| Contributors: | McPherson, T. (Author) Sherman, V. J. (Author) Aslam, A. (Author) Crack, L. (Author) Chan, H. (Author) Lloyd-Lavery, A. (Author) Jones, L.E. (Author) Ardern-Jones, M (Author) Ogg, G. (Author) |
| Date: | September 2010 |
| Status: | Published |
| URI: | http://eprints.soton.ac.uk/id/eprint/181625 |
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