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Inhibition of hydroxyapatite nanoparticle-induced osteogenic activity in skeletal cells by adsorption of serum proteins

Inhibition of hydroxyapatite nanoparticle-induced osteogenic activity in skeletal cells by adsorption of serum proteins
Inhibition of hydroxyapatite nanoparticle-induced osteogenic activity in skeletal cells by adsorption of serum proteins
Stimulation of osteogenesis in human bone marrow stromal cells by surface attachment and endocytosis of arginine-functionalized hydroxyapatite nanoparticles is enhanced when serum proteins are omitted from the culture medium for an initial 24 hour period. This effect, which is related to nanoparticle binding of the serum proteins, could be an important consideration in nanoparticle-induced bioactivity and nanotoxicity in general.

osteogenic nanoparticles, nanoparticle-induced bioactivity, skeletal repair, protein adsorption
1613-6810
1986-1991
Hails, Lauren A.
0db2a3de-0599-4a1d-89b6-5415544612f5
Babister, Jodie C.
3b35e463-b623-403c-91c3-88a590cea674
Inglis, Stefanie
cb950bb9-8b89-41c0-b547-3206580d16b4
Davis, Sean A.
b4bf65bc-72be-437f-a711-d6dafad5f3d1
Oreffo, Richard O.
ff9fff72-6855-4d0f-bfb2-311d0e8f3778
Mann, Stephan
eba3623e-46ed-4b41-b52a-61ce5d4c6063
Hails, Lauren A.
0db2a3de-0599-4a1d-89b6-5415544612f5
Babister, Jodie C.
3b35e463-b623-403c-91c3-88a590cea674
Inglis, Stefanie
cb950bb9-8b89-41c0-b547-3206580d16b4
Davis, Sean A.
b4bf65bc-72be-437f-a711-d6dafad5f3d1
Oreffo, Richard O.
ff9fff72-6855-4d0f-bfb2-311d0e8f3778
Mann, Stephan
eba3623e-46ed-4b41-b52a-61ce5d4c6063

Hails, Lauren A., Babister, Jodie C., Inglis, Stefanie, Davis, Sean A., Oreffo, Richard O. and Mann, Stephan (2010) Inhibition of hydroxyapatite nanoparticle-induced osteogenic activity in skeletal cells by adsorption of serum proteins. Small, 6 (18), 1986-1991. (doi:10.1002/smll.201000939). (PMID:20721953)

Record type: Article

Abstract

Stimulation of osteogenesis in human bone marrow stromal cells by surface attachment and endocytosis of arginine-functionalized hydroxyapatite nanoparticles is enhanced when serum proteins are omitted from the culture medium for an initial 24 hour period. This effect, which is related to nanoparticle binding of the serum proteins, could be an important consideration in nanoparticle-induced bioactivity and nanotoxicity in general.

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More information

Published date: September 2010
Keywords: osteogenic nanoparticles, nanoparticle-induced bioactivity, skeletal repair, protein adsorption

Identifiers

Local EPrints ID: 181651
URI: http://eprints.soton.ac.uk/id/eprint/181651
DOI: doi:10.1002/smll.201000939
ISSN: 1613-6810
PURE UUID: 12f3bf1a-f83b-4260-9a6d-6bee2a12ac98
ORCID for Richard O. Oreffo: ORCID iD orcid.org/0000-0001-5995-6726

Catalogue record

Date deposited: 18 Apr 2011 14:45
Last modified: 15 Mar 2024 03:03

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Contributors

Author: Lauren A. Hails
Author: Jodie C. Babister
Author: Stefanie Inglis
Author: Sean A. Davis
Author: Richard O. Oreffo ORCID iD
Author: Stephan Mann

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