Inhibition of hydroxyapatite nanoparticle-induced osteogenic activity in skeletal cells by adsorption of serum proteins
Hails, Lauren A., Babister, Jodie C., Inglis, Stefanie, Davis, Sean A., Oreffo, Richard O. and Mann, Stephan (2010) Inhibition of hydroxyapatite nanoparticle-induced osteogenic activity in skeletal cells by adsorption of serum proteins. Small, 6, (18), 1986-1991. (doi:10.1002/smll.201000939). (PMID:20721953).
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Stimulation of osteogenesis in human bone marrow stromal cells by surface attachment and endocytosis of arginine-functionalized hydroxyapatite nanoparticles is enhanced when serum proteins are omitted from the culture medium for an initial 24 hour period. This effect, which is related to nanoparticle binding of the serum proteins, could be an important consideration in nanoparticle-induced bioactivity and nanotoxicity in general.
|Digital Object Identifier (DOI):||doi:10.1002/smll.201000939|
|Keywords:||osteogenic nanoparticles;, nanoparticle-induced bioactivity, skeletal repair, protein adsorption|
|Subjects:||Q Science > QR Microbiology
R Medicine > RB Pathology
R Medicine > RM Therapeutics. Pharmacology
|Divisions:||University Structure - Pre August 2011 > School of Medicine > Developmental Origins of Health and Disease
|Date Deposited:||18 Apr 2011 14:45|
|Last Modified:||14 Apr 2014 10:57|
Cell Modification in 3D: a new Paradigm in the Creation of Living Cell-Biomaterial Composites
Funded by: EPSRC (EP/D062349/1)
Led by: Richard Oreffo
2 October 2006 to 1 April 2010
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