Evaluating the clonal hierarchy in light-chain multiple myeloma: implications against the myeloma stem cell hypothesis
Pfeifer, Sabine, Perez-Andres, Martin, Ludwig, Heinz, Sahota , Surinder S. and Zojer, Niklas (2011) Evaluating the clonal hierarchy in light-chain multiple myeloma: implications against the myeloma stem cell hypothesis. Leukemia (doi:10.1038/leu.2011.70). (PMID:21494259).
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An exclusive production of light chains can be found in ~15% of myeloma cases, and in these light-chain multiple myeloma (LC-MM) cases, the phenotype remains unchanged throughout subsequent progression and relapse. Once established, it suggests that this phenotype is maintained by the ‘feeder cell’ that re-populates the tumor bulk as disease re-emerges.
|Subjects:||Q Science > QR Microbiology > QR180 Immunology
R Medicine > RB Pathology
R Medicine > RC Internal medicine > RC0254 Neoplasms. Tumors. Oncology (including Cancer)
|Divisions:||University Structure - Pre August 2011 > School of Medicine > Cancer Sciences
|Date Deposited:||19 Apr 2011 14:11|
|Last Modified:||19 Jul 2012 09:59|
|Contributors:||Pfeifer, Sabine (Author)
Perez-Andres, Martin (Author)
Ludwig, Heinz (Author)
Sahota , Surinder S. (Author)
Zojer, Niklas (Author)
|Date:||15 April 2011|
|RDF:||RDF+N-Triples, RDF+N3, RDF+XML, Browse.|
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