Evaluating the clonal hierarchy in light-chain multiple myeloma: implications against the myeloma stem cell hypothesis
Pfeifer, Sabine, Perez-Andres, Martin, Ludwig, Heinz, Sahota , Surinder S. and Zojer, Niklas (2011) Evaluating the clonal hierarchy in light-chain multiple myeloma: implications against the myeloma stem cell hypothesis. Leukemia (doi:10.1038/leu.2011.70). (PMID:21494259).
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Description/Abstract
An exclusive production of light chains can be found in ~15% of myeloma cases, and in these light-chain multiple myeloma (LC-MM) cases, the phenotype remains unchanged throughout subsequent progression and relapse. Once established, it suggests that this phenotype is maintained by the ‘feeder cell’ that re-populates the tumor bulk as disease re-emerges.
| Item Type: | Article |
|---|---|
| ISSNs: | 0887-6924 (print) 0887-6924 (electronic) |
| Subjects: | Q Science > QR Microbiology > QR180 Immunology R Medicine > RB Pathology R Medicine > RC Internal medicine > RC0254 Neoplasms. Tumors. Oncology (including Cancer) |
| Divisions: | University Structure - Pre August 2011 > School of Medicine > Cancer Sciences |
| Item ID: | 181785 |
| Date Deposited: | 19 Apr 2011 14:11 |
| Last Modified: | 19 Jul 2012 09:59 |
| Contributors: | Pfeifer, Sabine (Author) Perez-Andres, Martin (Author) Ludwig, Heinz (Author) Sahota , Surinder S. (Author) Zojer, Niklas (Author) |
| Date: | 15 April 2011 |
| Status: | Published |
| URI: | http://eprints.soton.ac.uk/id/eprint/181785 |
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