Intracellular kinases in semaphorin signaling
Ahmed, Aminul and Eickholt, Britta J. (2007) Intracellular kinases in semaphorin signaling. In, Pasterkamp, Gerard (ed.) Semaphorins: Receptor and Intracellular Signaling Mechanisms. New York, US, Springer, 24-37. (Advances in Experimental Medicine and Biology, 600).
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Description/Abstract
Originally identified as collapse-inducing and repellent proteins for neuronal processes, semaphorins are now implicated in a diverse array of cellular responses, contributing not only to embryonic development, but also to the maintenance of tissue integrity in the adult organism. In addition, semaphorins play a role in the pathological context. Some Semaphorins can act at a distance, facilitating the navigation of cells or axonal process, whilst others evoke responses in a contact-dependent fashion. The intracellular signaling mechanisms employed by the semaphorins are beginning to be determined, and much work in recent years implicates a host of intracellular kinases in mediating Semaphorin function. These include the tyrosine kinase Fyn and the serine/threonine kinases Cdk5, GSK3, MAPK, and LIMK, and the lipid kinase PI3K. What follows is a review of this work with respect to their functions in mediating specific semaphorin-induced responses.
| Item Type: | Book Section |
|---|---|
| ISBN: | 9780387709550 (hardback) 9781441924278 (paperback) |
| Related URLs: | http://www.springer.com/biomed...87-70955-0 |
| Subjects: | R Medicine > R Medicine (General) |
| Divisions: | University Structure - Pre August 2011 > School of Medicine |
| ePrint ID: | 183441 |
| URI: | http://eprints.soton.ac.uk/id/eprint/183441 |
| Deposited On: | 11 May 2011 10:06 |
| Last Modified: | 02 Mar 2012 13:38 |
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