Genes and environment in asthma: a study of 4 year old twins
Koeppen-Schomerus, G., Stevenson, J. and Plomin, R. (2001) Genes and environment in asthma: a study of 4 year old twins. Archives of Disease in Childhood, 85, (5), 398-400.
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BACKGROUND - Although the genetic and environmental factors of asthma have been investigated in adolescence and adulthood, no previous studies have focused on the early development of asthma.
AIMS - To test, in a large sample of 4 year old twins, the hypotheses derived from the literature on adolescents and adults that genetic influences are substantial and shared environmental influences are modest.
METHODS - The sample consisted of 4910 twin pairs who were born in England and Wales in 1994 and 1995. Data on asthma status were obtained from the twins' parents by postal questionnaire.
RESULTS - Univariate parameter estimates derived from model fitting were 68% heritability, 13% shared environment, and 19% non-shared environment.
CONCLUSIONS - Our findings suggest that asthma is highly heritable in 4 year olds, whereas shared environmental influences are not statistically significant.
|Keywords:||twin studies, risk factors, asthma, genetics|
|Subjects:||Q Science > QH Natural history > QH426 Genetics
B Philosophy. Psychology. Religion > BF Psychology
R Medicine > RJ Pediatrics > RJ101 Child Health. Child health services
|Divisions:||University Structure - Pre August 2011 > School of Psychology > Division of Clinical Neuroscience
|Date Deposited:||06 Jan 2006|
|Last Modified:||01 Jun 2011 03:52|
|Contributors:||Koeppen-Schomerus, G. (Author)
Stevenson, J. (Author)
Plomin, R. (Author)
|RDF:||RDF+N-Triples, RDF+N3, RDF+XML, Browse.|
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