Genes and environment in asthma: a study of 4 year old twins


Koeppen-Schomerus, G., Stevenson, J. and Plomin, R. (2001) Genes and environment in asthma: a study of 4 year old twins. Archives of Disease in Childhood, 85, (5), 398-400.

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Description/Abstract

BACKGROUND - Although the genetic and environmental factors of asthma have been investigated in adolescence and adulthood, no previous studies have focused on the early development of asthma.

AIMS - To test, in a large sample of 4 year old twins, the hypotheses derived from the literature on adolescents and adults that genetic influences are substantial and shared environmental influences are modest.

METHODS - The sample consisted of 4910 twin pairs who were born in England and Wales in 1994 and 1995. Data on asthma status were obtained from the twins' parents by postal questionnaire.

RESULTS - Univariate parameter estimates derived from model fitting were 68% heritability, 13% shared environment, and 19% non-shared environment.

CONCLUSIONS - Our findings suggest that asthma is highly heritable in 4 year olds, whereas shared environmental influences are not statistically significant.

Item Type: Article
Related URLs:
Keywords: twin studies, risk factors, asthma, genetics
Subjects: Q Science > QH Natural history > QH426 Genetics
B Philosophy. Psychology. Religion > BF Psychology
R Medicine > RJ Pediatrics > RJ101 Child Health. Child health services
Divisions: University Structure - Pre August 2011 > School of Psychology > Division of Clinical Neuroscience
ePrint ID: 18372
Date Deposited: 06 Jan 2006
Last Modified: 27 Mar 2014 18:08
URI: http://eprints.soton.ac.uk/id/eprint/18372

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