Effect of honey and its major royal jelly protein 1 on cytokine and MMP-9 mRNA transcripts in human keratinocytes

Majtan, Juraj, Kumar, Pawan, Majtan, Tomas, Walls, Andrew F. and Klaudiny, Jaroslav (2010) Effect of honey and its major royal jelly protein 1 on cytokine and MMP-9 mRNA transcripts in human keratinocytes. Experimental Dermatology, 19, (8), e73-e79. (doi:10.1111/j.1600-0625.2009.00994.x). (PMID:19845754).


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Honey has been used since ancient times as a remedy in wound healing. However, even though the results from randomized clinical trials document that honey accelerates wound healing, no study dealing with its influence on human skin cells (epidermal keratinocytes and dermal fibroblast) has been performed. We demonstrate that keratinocytes, which are known to be involved in wound healing, are responsible for elevated production of mediators including cytokines (TNF-?, IL-1? and TGF-?) and matrix metalloproteinase-9 (MMP-9) after incubation with honey. Real-time PCR was performed for the quantification of mRNA level of selected cytokines and MMP-9. Furthermore, we show that the increased level of MMP-9 in the epidermis following incubation with honey leads to degradation of type IV collagen in the basement membrane. These data indisputably demonstrate that honey activates keratinocytes and support the findings that honey may accelerate wound healing process.

Item Type: Article
Digital Object Identifier (DOI): doi:10.1111/j.1600-0625.2009.00994.x
ISSNs: 0906-6705 (print)
1600-0625 (electronic)
Keywords: honey, keratinocytes, major royal jelly protein 1, skin, wound healing
Subjects: Q Science > QR Microbiology > QR355 Virology
R Medicine > RL Dermatology
R Medicine > RZ Other systems of medicine
Divisions : University Structure - Pre August 2011 > School of Medicine > Infection, Inflammation and Repair
ePrint ID: 183805
Accepted Date and Publication Date:
August 2010Published
Date Deposited: 04 May 2011 09:19
Last Modified: 31 Mar 2016 13:37
URI: http://eprints.soton.ac.uk/id/eprint/183805

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