Blocked designs for experiments with correlated non-normal response

Woods, David C. and van de Ven, Peter (2011) Blocked designs for experiments with correlated non-normal response. Technometrics, 53, (2), 173-182. (doi:10.1198/TECH.2011.09197).


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Many experiments measure a response that cannot be adequately described by a linear model with normally distributed errors and are often run in blocks of homogeneous experimental units. We develop the first general methods of obtaining efficient blocked designs for experiments with an exponential family response described by a marginal model fitted via Generalized Estimating Equations. This methodology is appropriate when the blocking factor is a nuisance variable, as often occurs in industrial experiments. A D-optimality criterion is developed for finding designs robust to the values of the marginal model parameters and applied using two strategies: unrestricted algorithmic search and blocking of an optimal design for the corresponding Generalized Linear Model (GLM). Designs from each strategy are critically compared and shown to be more efficient than use of a random allocation to blocks of the points from an optimal GLM design. The designs are compared for a range of values of the intra-block working correlation and for exchangeable, autoregressive, and nearest-neighbor structures. A general equivalence theorem is provided for continuous blocked designs. An analysis strategy is developed for binary data that allows estimation from experiments with sparse data, and its effectiveness demonstrated. The design strategies are motivated and demonstrated through the planning of an experiment from the aeronautics industry.

Item Type: Article
Digital Object Identifier (DOI): doi:10.1198/TECH.2011.09197
ISSNs: 0040-1706 (print)
1537-2723 (electronic)
Subjects: H Social Sciences > HA Statistics
Q Science > QA Mathematics
Divisions : University Structure - Pre August 2011 > School of Mathematics > Statistics
University Structure - Pre August 2011 > Southampton Statistical Sciences Research Institute
ePrint ID: 184117
Accepted Date and Publication Date:
May 2011Published
Date Deposited: 05 May 2011 08:57
Last Modified: 31 Mar 2016 13:37
PLATFORM: End-to-End pipeline for chemical information: from the laboratory to literature and back again
Funded by: EPSRC (EP/C008863/1)
April 2005 to June 2010

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