Venous thromboembolic disease and combined oral contraceptives: A re-analysis of the Mediplus database

Todd, J.C., Lawrenson, R., Farmer, R.D., Williams, T.J. and Leydon, G.M. (1999) Venous thromboembolic disease and combined oral contraceptives: A re-analysis of the Mediplus database. Human Reproduction, 14, (6), 1500-1505. (doi:10.1093/humrep/14.6.1500). (PMID:10357966).


Full text not available from this repository.


In October 1995 the Committee on Safety of Medicines advised UK doctors and pharmacists that oral contraceptives containing desogestrel and gestodene were associated with double the risk of venous thromboembolic events (VTE) compared to pills containing other progestogens. In 1997 data was analysed from the MediPlus database of UK general practitioner records, which reported odds ratios for desogestrel and gestodene lower than that for levonorgestrel. Here the results of a more stringent nested case control analysis on the MediPlus database are reported. The study was larger and cases were verified. A crude incidence of idiopathic VTE was found amongst users of combined oral contraceptives of 4.6 per 10 000 exposed women years. Using levonorgestrel 150 μg + ethinyloestradiol 30 μg as reference, non-significant odds ratios of 1.1 (0.5–2.6) for desogestrel 150 μg + ethinyloestradiol 30 μg and 1.1 (0.5–2.4) for gestodene 75 μg + ethinyloestradiol 30 μg were found. The results of this study show no significant difference in risk between different formulations of combined oral contraceptive.

Item Type: Article
ISSNs: 0268-1161 (print)
1460-2350 (electronic)
Keywords: case control, oral contraceptives, pill scare, study mediplus databaes, venous thromboembolic disease
Subjects: R Medicine > RG Gynecology and obstetrics
R Medicine > RM Therapeutics. Pharmacology
R Medicine > RS Pharmacy and materia medica
Divisions: University Structure - Pre August 2011 > School of Medicine > Community Clinical Sciences
ePrint ID: 184367
Date Deposited: 05 May 2011 14:39
Last Modified: 27 Mar 2014 19:39

Actions (login required)

View Item View Item