Increased preconception omega-3 polyunsaturated fatty acid intake improves embryo morphology

Hammiche, Fatima, Vujkovic, Marijana, Wilburg, Willeke, de Vries, Jeanne H.M., Macklon, Nick S., Laven, Joop S.E. and Steegers-Theunissen, Régine P.M. (2011) Increased preconception omega-3 polyunsaturated fatty acid intake improves embryo morphology. Fertility and Sterility, 95, (5), 1820-1823. (doi:10.1016/j.fertnstert.2010.11.021). (PMID:21130435).


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The association between preconception dietary intake of the polyunsaturated fatty acids (LC-PUFAs) omega-6 and omega-3 and the E(2) levels and IVF/intracytoplasmic sperm injection (ICSI) outcome were investigated in women in a prospective study. It revealed that high intakes of omega-3 LC-PUFA alpha-linolenic acid increase baseline E(2), high intakes of eicosapentaenoic acid and docosahexaenoic acid reduce E(2) response and the number of follicles after ovarian stimulation, and total omega-3 intake, in particular alpha-linolenic acid and docosahexaenoic acid, improve embryo morphology.

Item Type: Article
Digital Object Identifier (DOI): doi:10.1016/j.fertnstert.2010.11.021
ISSNs: 0015-0282 (print)
Keywords: nutrition, assisted reproduction, fertility outcome
Subjects: R Medicine > RG Gynecology and obstetrics
Divisions : University Structure - Pre August 2011 > School of Medicine > Developmental Origins of Health and Disease
ePrint ID: 185235
Accepted Date and Publication Date:
April 2011Published
Date Deposited: 10 May 2011 08:37
Last Modified: 31 Mar 2016 13:38

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