Cardiovascular and metabolic characteristics of infertile Chinese women with PCOS diagnosed according to the Rotterdam consensus criteria
Guo, M., Chen, Z.J., Macklon, N.S., Westerveld, H.E., Eijkemans, M.J., Fauser, B.C. and Goverde, A.J. (2010) Cardiovascular and metabolic characteristics of infertile Chinese women with PCOS diagnosed according to the Rotterdam consensus criteria. Reproductive BioMedicine Online, 21, (4), 572-580. (doi:10.1016/j.rbmo.2010.04.032). (PMID:20800551).
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Polycystic ovary syndrome (PCOS) is strongly associated with metabolic abnormalities in Western women. However, data from other populations and geographical regions are scarce. This study evaluated cardiovascular and metabolic risk factors in Chinese infertile women diagnosed with PCOS using the 2003 Rotterdam consensus criteria. A total of 615 women representing the four PCOS phenotypes (oligo- or anovulation (AO) + hyperandrogenism (HA) + polycystic ovaries (PCO), AO + HA, AO + PCO and HA + PCO) underwent standardized metabolic screening including a 75 g oral glucose tolerance test. All groups presented with similar reproductive characteristics, with the only difference being a significantly higher Ferriman–Gallwey score for hirsutism (P = 0.01) in the subgroup characterized by HA + PCO. Overall, the prevalence of metabolic syndrome was 6.4%, with no difference among the four groups (range of 2.3–12.2%). Metabolic syndrome was associated with body mass index (P < 0.001), waist/hip ratio (P = 0.002), index of insulin resistance (P = 0.005) and fasting insulin (P = 0.009) in multivariate analysis. Compared with Caucasians and Chinese women in Westernized societies, mainland Chinese women with PCOS have a low risk of metabolic syndrome and its presence does not vary across the specific PCOS phenotypes.
|Keywords:||ethnicity, infertility, insulin resistance, metabolic syndrome, polycystic ovary syndrome|
|Subjects:||H Social Sciences > HA Statistics
R Medicine > RB Pathology
R Medicine > RG Gynecology and obstetrics
|Divisions:||University Structure - Pre August 2011 > School of Medicine > Developmental Origins of Health and Disease
|Date Deposited:||10 May 2011 08:58|
|Last Modified:||01 Jun 2011 03:27|
|Contributors:||Guo, M. (Author)
Chen, Z.J. (Author)
Macklon, N.S. (Author)
Westerveld, H.E. (Author)
Eijkemans, M.J. (Author)
Fauser, B.C. (Author)
Goverde, A.J. (Author)
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