The psychological impact of mild ovarian stimulation combined with single embryo transfer compared with conventional IVF


de Klerk, C., Heijnen, E.M.E.W., Macklon, N.S., Duivenvoorden, H.J., Fauser, B.C.J.M., Passchier, J. and Hunfeld, J.A.M. (2006) The psychological impact of mild ovarian stimulation combined with single embryo transfer compared with conventional IVF. Human Reproduction, 21, (3), 721-727. (doi:10.1093/humrep/dei395). (PMID:16311295).

Download

Full text not available from this repository.

Description/Abstract

Background: The objective of this study was to assess the psychological implications of mild ovarian stimulation combined with single embryo transfer (SET) during a first IVF cycle.

Methods: We conducted a randomized controlled two-centre trial. Three hundred and ninety-one couples were randomized to undergo either mild ovarian stimulation with GnRH antagonist co-treatment and SET (n = 199) or conventional GnRH agonist long protocol ovarian stimulation with double embryo transfer (DET) (n = 192). Women completed the Hospital Anxiety and Depression Scale, the Hopkins Symptom Checklist and the Subjective Sleep Quality Scale at baseline, on the first day of ovarian stimulation and following embryo transfer. Affect was assessed daily with the Daily Record Keeping Chart from the first day of ovarian stimulation until the day treatment outcome became known.

Results: The conventional IVF group experienced elevated levels of physical and depressive symptoms during pituitary downregulation. At oocyte retrieval, this group experienced more positive affect and less negative affect than the mild IVF group. In the conventional IVF group, cycle cancellation was associated with less positive and more negative affect.

Conclusions: During the first IVF treatment cycle, mild ovarian stimulation and SET does not lead to more psychological complaints than conventional IVF.

Item Type: Article
ISSNs: 0268-1161 (print)
1460-2350 (electronic)
Subjects: B Philosophy. Psychology. Religion > BF Psychology
R Medicine > RG Gynecology and obstetrics
R Medicine > RM Therapeutics. Pharmacology
Divisions: University Structure - Pre August 2011 > School of Medicine > Developmental Origins of Health and Disease
ePrint ID: 185625
Date Deposited: 19 May 2011 12:46
Last Modified: 27 Mar 2014 19:40
URI: http://eprints.soton.ac.uk/id/eprint/185625

Actions (login required)

View Item View Item