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Multiple birth resulting from ovarian stimulation for subfertility treatment

Multiple birth resulting from ovarian stimulation for subfertility treatment
Multiple birth resulting from ovarian stimulation for subfertility treatment
Assisted reproductive technologies (ARTs) aim to increase a woman's chances of becoming pregnant by bringing many female and male gametes into close proximity. Techniques to achieve this objective include ovarian hyperstimulation by maturation of several oocytes, intrauterine insemination (IUI) of concentrated sperm, or in-vitro fertilisation (IVF) by bringing gametes together outside the female body. The very nature of ovarian hyperstimulation--with or without IUI--enhances the risk of multiple pregnancy (eg, two or more babies). In most IVF cycles, more than one embryo is transferred, again resulting in an increased chance of multiple pregnancy. Developed societies have witnessed a large rise in prevalence of twin, triplet, and higher order multiple births, mainly resulting from ARTs. The primary aim of this Review is to increase awareness of the many implications of the present iatrogenic epidemic of multiple births. The background of ovarian hyperstimulation, trends supporting current practice, and strategies to reduce the chance of multiple pregnancy are highlighted.
0140-6736
1807-1816
Fauser, Bart C.J.M.
0edf5e0f-12db-4ca9-bf9c-00e85b7f4a3e
Devroey, Paul
f7983a73-cf6f-4bab-9aa6-e533f400a938
Macklon, Nick S.
7db1f4fc-a9f6-431f-a1f2-297bb8c9fb7e
Fauser, Bart C.J.M.
0edf5e0f-12db-4ca9-bf9c-00e85b7f4a3e
Devroey, Paul
f7983a73-cf6f-4bab-9aa6-e533f400a938
Macklon, Nick S.
7db1f4fc-a9f6-431f-a1f2-297bb8c9fb7e

Fauser, Bart C.J.M., Devroey, Paul and Macklon, Nick S. (2005) Multiple birth resulting from ovarian stimulation for subfertility treatment. The Lancet, 365 (9473), 1807-1816. (doi:10.1016/S0140-6736(05)66478-1). (PMID:16084249)

Record type: Article

Abstract

Assisted reproductive technologies (ARTs) aim to increase a woman's chances of becoming pregnant by bringing many female and male gametes into close proximity. Techniques to achieve this objective include ovarian hyperstimulation by maturation of several oocytes, intrauterine insemination (IUI) of concentrated sperm, or in-vitro fertilisation (IVF) by bringing gametes together outside the female body. The very nature of ovarian hyperstimulation--with or without IUI--enhances the risk of multiple pregnancy (eg, two or more babies). In most IVF cycles, more than one embryo is transferred, again resulting in an increased chance of multiple pregnancy. Developed societies have witnessed a large rise in prevalence of twin, triplet, and higher order multiple births, mainly resulting from ARTs. The primary aim of this Review is to increase awareness of the many implications of the present iatrogenic epidemic of multiple births. The background of ovarian hyperstimulation, trends supporting current practice, and strategies to reduce the chance of multiple pregnancy are highlighted.

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More information

Published date: May 2005
Organisations: Dev Origins of Health & Disease

Identifiers

Local EPrints ID: 185633
URI: http://eprints.soton.ac.uk/id/eprint/185633
ISSN: 0140-6736
PURE UUID: 4ef75e8d-14c2-4786-b665-8b48a5f95332

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Date deposited: 19 May 2011 10:34
Last modified: 14 Mar 2024 03:14

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Contributors

Author: Bart C.J.M. Fauser
Author: Paul Devroey
Author: Nick S. Macklon

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