Reproductive biology and IVF: ovarian stimulation and endometrial receptivity

Devroey, Paul, Bourgain, Claire, Macklon, Nicholas S. and Fauser, Bart C. J. M. (2004) Reproductive biology and IVF: ovarian stimulation and endometrial receptivity. Trends in Endocrinology and Metabolism, 15, (2), 84-90. (doi:10.1016/j.tem.2004.01.009). (PMID:15036255).


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The influence of ovarian stimulation on endometrium receptivity has been inadequately addressed in medical literature. Hormonal effects of ovarian stimulation on endometrial changes as compared with the natural cycle should be elucidated and correlated with the potential of the embryo to implant. It is important to distinguish between the endometrial effect of induction of ovulation in anovulatory women and those of ovarian (super)ovulation in ovulatory women. Induction of ovulation leads to in vivo conception whereas ovarian stimulation results in in vitro fertilization. The available data in the field indicate that endometrial changes have an impressive negative influence on the potential of embryonic implantation. The aim of this review is to analyse the effects of gonadotropin, GnRH-agonist and GnRH-antagonist administration on endometrial behaviour, to highlight the gaps in current knowledge and to propose areas in which research is needed.

Item Type: Article
Digital Object Identifier (DOI): doi:10.1016/j.tem.2004.01.009
ISSNs: 1043-2760 (print)
Related URLs:
Subjects: R Medicine > R Medicine (General)
R Medicine > RG Gynecology and obstetrics
Divisions : University Structure - Pre August 2011 > School of Medicine > Developmental Origins of Health and Disease
ePrint ID: 185639
Accepted Date and Publication Date:
March 2004Published
Date Deposited: 19 May 2011 15:27
Last Modified: 31 Mar 2016 13:38

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