Mild stimulation in in vitro fertilization
Mild stimulation in in vitro fertilization
Current approaches to ovarian stimulation for in vitro fertilization (IVF) are aimed at optimizing the number of oocytes retrieved in a treatment cycle. This approach is not without risks. Moreover, as the true costs of multiple pregnancy become clearer, the need to produce multiple embryos for transfer is increasingly questioned. Increasing knowledge of the physiological mechanisms involved in follicular development and dominance has led to new strategies in ovarian stimulation for IVF. The clinical availability of GnRH antagonists allows the normal cycle to be harnessed and manipulated by mild interventions to produce sufficient oocytes for successful IVF treatment. Recent evidence suggests that oocyte quality after mild stimulation may be superior to that after conventional stimulation regimens.
in vitro fertilization (IVF, follicle selection, follicle-stimulating hormone (FSH) window, mild stimulation
105-111
Macklon, N. S.
7db1f4fc-a9f6-431f-a1f2-297bb8c9fb7e
Fauser, B. C. J. M.
c65d9f08-b6a6-420b-b2db-71ea7e3c4a8f
November 2003
Macklon, N. S.
7db1f4fc-a9f6-431f-a1f2-297bb8c9fb7e
Fauser, B. C. J. M.
c65d9f08-b6a6-420b-b2db-71ea7e3c4a8f
Abstract
Current approaches to ovarian stimulation for in vitro fertilization (IVF) are aimed at optimizing the number of oocytes retrieved in a treatment cycle. This approach is not without risks. Moreover, as the true costs of multiple pregnancy become clearer, the need to produce multiple embryos for transfer is increasingly questioned. Increasing knowledge of the physiological mechanisms involved in follicular development and dominance has led to new strategies in ovarian stimulation for IVF. The clinical availability of GnRH antagonists allows the normal cycle to be harnessed and manipulated by mild interventions to produce sufficient oocytes for successful IVF treatment. Recent evidence suggests that oocyte quality after mild stimulation may be superior to that after conventional stimulation regimens.
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Published date: November 2003
Keywords:
in vitro fertilization (IVF, follicle selection, follicle-stimulating hormone (FSH) window, mild stimulation
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Local EPrints ID: 185643
URI: http://eprints.soton.ac.uk/id/eprint/185643
ISSN: 0077-8923
PURE UUID: c910a15d-44f0-4c53-a081-6dc40bdcc342
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Date deposited: 20 May 2011 09:12
Last modified: 14 Mar 2024 03:14
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Author:
N. S. Macklon
Author:
B. C. J. M. Fauser
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