The added value of embryo cryopreservation to cumulative ongoing pregnancy rates per IVF treatment: is cryopreservation worth the effort?
de Jong, D., Eijkemans, M. J. C., Beckers, N. G. M., Pruijsten, R. V., Fauser, B C J M and Macklon, N. S. (2002) The added value of embryo cryopreservation to cumulative ongoing pregnancy rates per IVF treatment: is cryopreservation worth the effort? Journal of Assisted Reproduction and Genetics, 19, (12), 561-568. (PMID:12503888).
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Purpose: To calculate the added benefit of a cryopreservation program to the cumulative
ongoing pregnancy rate over a maximum of three cycles of IVF.
Methods: A total of 1251 couples beginning their first IVF treatment between January 1995
and December 1999 were evaluated. Ongoing pregnancies from fresh and subsequent cryopreserved
embryo transfer cycles were analyzed. Pregnancies arising from the cryopreservation
cycle were considered to augment the cumulative pregnancy rate when no ongoing pregnancy
arose from the fresh embryo transfer cycle.
Results: The ongoing pregnancy rate per cryopreserved embryo transfer was 11.7%. The
cumulative ongoing pregnancy rate following three successive started fresh IVF cycles was
42.5%. When pregnancies arising from the transfer of thawed cryopreserved embryos were
included, the cumulative ongoing pregnancy rate increased to 43.8%, rising to 44.8% when
extrapolated data from as yet unthawed embryos was included.
Conclusions: When analyzed in these terms, the supplementary benefit of cryopreserving
supranumerical embryos appears limited.
|Keywords:||blastocyst, cryopreservation, embryo, ethics, health economics, IVF, minimal ovarian stimulation, pregnancy|
|Subjects:||R Medicine > R Medicine (General)
R Medicine > RG Gynecology and obstetrics
|Divisions:||University Structure - Pre August 2011 > School of Medicine > Developmental Origins of Health and Disease
|Date Deposited:||20 May 2011 10:33|
|Last Modified:||27 Mar 2014 19:40|
|RDF:||RDF+N-Triples, RDF+N3, RDF+XML, Browse.|
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