Conception to ongoing pregnancy: the 'black box' of early pregnancy loss

Macklon, N. S., Geraedts, J. P. M and Fauser, B. C. J. M. (2002) Conception to ongoing pregnancy: the 'black box' of early pregnancy loss. Human Reproduction Update, 8, (4), 333-343. (doi:10.1093/humupd/8.4.333). (PMID:12206468).


Full text not available from this repository.


Even when conditions are optimal, the maximum chance of a clinically recognized pregnancy occurring in a given menstrual cycle is 30-40%. Increasing evidence points to preclinical pregnancy loss rather than failure of conception as the principal cause for the relatively low fecundity observed in humans. While sensitive assays for hCG have provided a glimpse of the events occurring between implantation and the missed menstrual period, new cytogenetic techniques have further opened this 'black box', providing novel insights into the causes of early pregnancy wastage. In this article, the evidence and causes of preclinical or 'occult' pregnancy are reviewed, and the implications for the infertile patient are addressed.

Item Type: Article
Digital Object Identifier (DOI): doi:10.1093/humupd/8.4.333
ISSNs: 1355-4786 (print)
1460-2369 (electronic)
Related URLs:
Keywords: aneuploidy, early pregnancy loss, human chorionic gonadotrophin, infertility, IVF
Subjects: R Medicine > R Medicine (General)
R Medicine > RG Gynecology and obstetrics
Divisions : University Structure - Pre August 2011 > School of Medicine > Developmental Origins of Health and Disease
ePrint ID: 185663
Accepted Date and Publication Date:
July 2002Published
Date Deposited: 11 May 2011 13:39
Last Modified: 31 Mar 2016 13:38

Actions (login required)

View Item View Item